Month: February 2023

An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase was written by Ullah, Nisar;Haladu, Shamsuddeen A.;Mosa, Basem A.. And the article was included in Tetrahedron Letters in 2011.Name: 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

An improved total synthesis of spermatinamine (I), an inhibitor of the anticancer target isoprenylcysteine carboxy methyltransferase (no biol. testing data presented), was accomplished starting from the com. available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Name: 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis and antibacterial activity of novel ketolides bearing an aryltetrazolyl-substituted alkyl side chain was written by Song, Qiu-Ling;Guo, Bao-Qin;Zhang, Wen;Lan, Ping;Sun, Ping-Hua;Chen, Wei-Min. And the article was included in Journal of Antibiotics in 2011.Application of 954-81-4 This article mentions the following:

A set of 17 novel ketolides bearing an aryltetrazolyl-substituted alkyl side chain were synthesized and evaluated for their antibacterial activities, which the aryltetrazolyl group was selected to replace the hetero-aryl moiety of the side chain in telithromycin for designing new compounds The synthesis of aryltetrazolyl alkylamines was reported in detail. The antibacterial activities of new ketolides were evaluated against a number of pathogens including macrolide-resistant organisms by using telithromycin as the reference Many of the evaluated compounds exhibited remarkable activities against both erythromycin-susceptible and erythromycin-resistant organisms such as Staphylococcus aureus (except S. aureus AD-08), Pseudomonas aeruginosa and Escherichia coli. Among these, the compound 11e exhibited excellent antibacterial potency against all the strains in comparison with others. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Application of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electroorganic chemistry. 91. A novel base useful for synthesis of esters and macrolides was written by Shono, Tatsuya;Ishige, Osamu;Uyama, Hiroshi;Kashimura, Shigenori. And the article was included in Journal of Organic Chemistry in 1986.Category: bromides-buliding-blocks This article mentions the following:

The anionic species (I) formed by the electroreduction of 2-pyrrolidone in DMF in the presence of tetraalkylammonium salts was a highly efficient base for the esterification of acids such as gibberellic and 6-aminopenicillanic acids which are not always stable under the usual esterification conditions. I was also useful for the selective transformation of 锠?halo carboxylic acids to the corresponding macrolides. The effect of the bulkiness of the supporting electrolytes on the selectivity of formation of macrolides over diolides was also discussed. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Category: bromides-buliding-blocks).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of heptakis(2-O-methyl)-灏?cyclodextrin was written by Takeo, Kenichi;Kuge, Takashi. And the article was included in Staerke in 1976.Synthetic Route of C42H63Br7O28 This article mentions the following:

The title compound, I (R = OH, R1 = Me) (II), was prepared in 80% yield by methylation of I (R = Br, R1 = H) with Me2SO4-BaO-Ba(OH)2 in DMF at room temperature for 40 hr, followed by treatment with NaOBz in (Me2N)3PO at 90鎺?and deesterification with NaOMe in MeOH. NMR comparison of II and the tetradeca-O-methyl ether (III) of 灏?dextrin confirmed that the Me groups in III are located at O-2 and O-6. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 was written by Vieira, Debora F.;Choi, Jun Yong;Calvet, Claudia M.;Siqueira-Neto, Jair Lage;Johnston, Jonathan B.;Kellar, Danielle;Gut, Jiri;Cameron, Michael D.;McKerrow, James H.;Roush, William R.;Podust, Larissa M.. And the article was included in Journal of Medicinal Chemistry in 2014.Computed Properties of C8H6BrFO2 This article mentions the following:

Chagas disease is a chronic infection in humans caused by Trypanosoma cruzi and manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction. Limited therapeutic options to prevent and treat Chagas disease put 8 million people infected with T. cruzi worldwide at risk. CYP51, involved in the biosynthesis of the membrane sterol component in eukaryotes, is a promising drug target in T. cruzi. We report the structure-activity relationships (SAR) of an N-arylpiperazine series of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors designed to probe the impact of substituents in the terminal N-Ph ring on binding mode, selectivity and potency. Depending on the substituents at C-4, two distinct ring binding modes, buried and solvent-exposed, have been observed by X-ray structure anal. (resolution of 1.95-2.48 鑴?. The 5-chloro-substituted analogs 9 and 10 with no substituent at C-4 demonstrated improved selectivity and potency, suppressing 閳?9.8% parasitemia in mice when administered orally at 25 mg/kg, b.i.d., for 4 days. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Computed Properties of C8H6BrFO2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photocatalyzed site-selective C(sp³)-H sulfonylation of toluene derivatives and cycloalkanes with inorganic sulfinates was written by Zhang, Shaonan;Cao, Shi;Lin, Yu-Mei;Sha, Liyuan;Lu, Cheng;Gong, Lei. And the article was included in Chinese Journal of Catalysis in 2022.SDS of cas: 57293-19-3 This article mentions the following:

Herein, a convenient and economic approach to site-selective C(sp3)-H sulfonylation via photo-induced HAT catalysis was reported. Employing a conjugated polycyclic quinone as a direct HAT photocatalyst, com. available inorganic sulfinates as the sulfonylation source, copper triflate as an inexpensive oxidant, a variety of toluene derivatives and cycloalkanes were converted into biol. and synthetically interesting sulfone products I [Ar = 4-MeC₆H₄, 4-EtC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, Me; R² = Me, Et, Ph, etc.; R³ = Ph, Et, i-Pr, etc.], II [R⁴ = cyclopentyl, cyclohexyl, cycloheptyl, etc.] under mild conditions. The mechanistic studies reveal that the reaction sequence involved direct HAT-induced radical formation and a subsequent copper-mediated organometallic process for the C-S bond formation. This method offered an appealing opportunity to furnish high value-added products from abundant hydrocarbon starting materials and inexpensive reagents. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3SDS of cas: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One-Pot Preparation of (NH)-Phenanthridinones and Amide-Functionalized [7]Helicene-like Molecules from Biaryl Dicarboxylic Acids was written by Murai, Takuya;Xing, Yongning;Kurokawa, Mayu;Kuribayashi, Toshifumi;Nikaido, Masanori;Elboray, Elghareeb E.;Hamada, Shohei;Kobayashi, Yusuke;Sasamori, Takahiro;Kawabata, Takeo;Furuta, Takumi. And the article was included in Journal of Organic Chemistry in 2022.Electric Literature of C8H6BrFO2 This article mentions the following:

A one-pot transformation of biaryl dicarboxylic acids to (NH)-phenanthridinone derivatives based on a Curtius rearrangement and subsequent basic hydrolysis was developed. This method is also applicable for the preparation of optically active amide-functionalized [7]helicene-like mols. Furthermore, aza[5]helicene derivatives with a phosphate moiety were isolated as a product of the Curtius rearrangement step in the case of substrates that bear chalcogen atoms. The stereostructures of these products, revealed by X-ray diffraction anal., suggested that chalcogen-bonding and pnictogen-bonding interactions might contribute to their stabilization. The configurational stability of the helicene-like mols. and their chiroptical properties were further investigated. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Electric Literature of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Magnetic glyconanoparticles for selective lectin separation and purification was written by Oz, Yavuz;Abdouni, Yamin;Yilmaz, Gokhan;Becer, C. Remzi;Sanyal, Amitav. And the article was included in Polymer Chemistry in 2019.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

A modular platform for the separation and purification of lectins using polymer coated iron oxide nanoparticles is developed. Supramol. host-guest interactions based on an adamantane beta-cyclodextrin (灏?CD) dyad are utilized to modify the polymeric interface. Poly(ethylene glycol) based hydrophilic polymer-coated magnetic iron oxide nanoparticles are fabricated using reversible addition-fragmentation chain transfer polymerization, followed by their chain-end modification to install adamantane groups on the nanoparticle surface. These adamantyl containing nanoparticles could be surface modified using 灏?CDs appended with appropriate ligands for intended applications. In this study, we exploit this supramol. system for the purpose of separation and purification of lectins. Therefore, a polymer-coated magnetic nanoparticle interface was decorated with two types of mannose-containing 灏?CD constructs, a monodisperse heptamannose conjugated CD and a CD-based 7-arm star shaped glycopolymer for selective binding towards the Con A (ConA) lectin. The monodisperse and polydisperse CD derivatives were compared in terms of their efficiency for binding to ConA. It was demonstrated that the polymeric CD construct significantly improved the binding of magnetic nanoparticles and provided an effective system for the separation and purification of ConA from a mixture of ConA and peanut agglutinin (PNA). Moreover, the surface bound isolated protein could be simply regenerated by the addition of competitive ligands such as mannose. Specificity to bind a particular lectin can be tailored by choosing the appropriate sugar based ligand, as demonstrated by the specific capture of PNA using a galactose-containing polymer. The modular nature of functionalization of the nanoparticle interface that is tunable by host-guest chem. affords a universal system that can be easily tailored for the purification of specific proteins from mixtures In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-mediated Intermolecular C-H aminohalogenation of Indoles at Room Temperature was written by Lu, Yuanhui;Zhang, Xiaoxiang;Xiao, Xiaoyu;Huang, Ninghua;Dou, Yadong;Liu, Chenrui;Wei, Wanxing;Zhang, Zhuan;Liang, Taoyuan. And the article was included in Asian Journal of Organic Chemistry in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

An efficient intermol. C-H aminohalogenation of indoles with azoles and NXS (X=F, Cl, Br, I) was developed to provide 2-azolyl-3-halogenated indoles I [R = H, 6-Me, 5-OMe, etc.; R¹ = 4-Br-1H-pyrazol-1-yl, 4-Cl-1H-pyrazol-1-yl, 4-Br-3,5-(Me)₂-1H-pyrazol-1-yl, etc.; R² = Me, Et, Bn, etc.; R³ = F, Cl, Br, I] in one single operation. In addition, this attractive route for the synthesis of compounds I was of great significance due to the product’s versatile reactivity for further transformations. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lipid composition, fatty acids and sterols in the seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): an analysis from nutritional, chemotaxonomic, and antiproliferative activity perspectives was written by Kendel, Melha;Wielgosz-Collin, Gaetane;Bertrand, Samuel;Roussakis, Christos;Bourgougnon, Nathalie;Bedoux, Gilles. And the article was included in Marine Drugs in 2015.Electric Literature of C15H29BrO2 This article mentions the following:

Lipids from the proliferative macroalgae Ulva armoricana (Chlorophyta) and Solieria chordalis (Rhodophyta) from Brittany, France, were investigated. The total content of lipids was 2.6% and 3.0% dry weight for U. armoricana and S. chordalis, resp. The main fractions of S. chordalis were neutral lipids (37%) and glycolipids (38%), whereas U. armoricana contained mostly neutral lipids (55%). Polyunsaturated fatty acids (PUFA) represented 29% and 15% of the total lipids in U. armoricana and S. chordalis, resp. In both studied algae, the phospholipids were composed of PUFA for 18%. In addition, PUFA were shown to represent 9% and 4.5% of glycolipids in U. armoricana and S. chordalis, resp. The essential PUFA were 16:4n-3, 18:4n-3, 18:2n-3, 18:2n-6, and 22:6n-3 in U. armoricana, and 20:4n-6 and 20:5n-3 in S. chordalis. It is important to notice that six 2-hydroxy-, three 3-hydroxy-, and two monounsaturated hydroxy fatty acids were also identified and may provide a chemotaxonomic basis for algae. These seaweeds contained interesting compounds such as squalene, 浼?tocopherol, cholest-4-en-3-one and phytosterols. The antiproliferative effect was evaluated in vitro on human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) with an IC₅₀ of 23 娓璯/mL for monogalactosyldiacylglycerols isolated from S. chordalis and 24 娓璯/mL for digalactosyldiacylglycerols from U. armoricana. These results confirm the potentialities of valorization of these two species in the fields of health, nutrition and chemotaxonomy. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Electric Literature of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary