Month: February 2023

Total Synthesis of Dictyodendrins B and E was written by Liang, Jingjing;Hu, Weimin;Tao, Pengyu;Jia, Yanxing. And the article was included in Journal of Organic Chemistry in 2013.Computed Properties of C9H11BrO This article mentions the following:

The concise synthesis of the novel telomerase inhibitors dictyodendrins B and E, I and II, resp., was completed in only 9 and 11 steps (longest linear sequence). The highly convergent strategy employed a palladium-catalyzed Larock indole synthesis and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction as key steps. The present synthesis exhibits respectable levels of atom-, redox-, and step-economy. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A multifunctional aggregation-induced emission (AIE)-active fluorescent chemosensor for detection of Zn²⁺ and Hg²⁺ was written by Tang, Aling;Yin, Ya;Chen, Zhao;Fan, Congbin;Liu, Gang;Pu, Shouzhi. And the article was included in Tetrahedron in 2019.COA of Formula: C12H7BrN2 This article mentions the following:

An aggregation-induced emission (AIE)-active fluorescent chemosensor based on a tetraphenylethene (TPE) unit was successfully designed and synthesized. The luminogen could detect Zn²⁺ selectively in a THF solution with the detection limit of 1.24 鑴?10^-6 mol L^-1. Meanwhile, the luminogen could also detect Hg²⁺ selectively in a THF-water mixture with the water content of 90%, and the detection limit was 2.55 鑴?10^-9 mol L^-1. Also, the solid-state mechanochromic fluorescence behavior of the luminogen was studied systematically. Indeed, the AIE-active luminogen also exhibited reversible mechanofluorochromic phenomenon involving fluorescent color change from blue to green, and powder x-ray diffraction results indicated that the switchable morphol. conversion between crystalline and amorphous states was responsible for this mechanochromism phenomenon. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8COA of Formula: C12H7BrN2).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C12H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-Activity Relationships of 9-Substituted-9-Dihydroerythromycin-Based Motilin Agonists: Optimizing for Potency and Safety was written by Shaw, Simon J.;Chen, Yue;Zheng, Hao;Fu, Hong;Burlingame, Mark A.;Marquez, Saul;Li, Yong;Claypool, Mark;Carreras, Christopher W.;Crumb, William;Hardy, Dwight J.;Myles, David C.;Liu, Yaoquan. And the article was included in Journal of Medicinal Chemistry in 2009.Formula: C8H7BrO2 This article mentions the following:

A series of 9-dihydro-9-acetamido-N-desmethyl-N-iso-Pr erythromycin A analogs and related derivatives was generated as motilin agonists. The compounds were optimized for potency while showing both minimal antibacterial activity and hERG inhibition. As the substituent on the amide was increased in lipophilicity the potency and hERG inhibition increased, while polar groups lowered potency, without significantly impacting hERG inhibition. The N-Me acetamide (7a) showed the optimal in vitro profile and was probed further by varying the chain length to the macrocycle as well as changing the macrocycle scaffold. Compound 7a remained the compound with the best in vitro properties. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Formula: C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs was written by Becker, Lisa F.;Schwarz, Dennis H.;Wenz, Gerhard. And the article was included in Beilstein Journal of Organic Chemistry in 2014.Electric Literature of C42H63Br7O28 This article mentions the following:

Me and Et thioether groups were introduced at all primary positions of 浼?, 灏?, and 绾?cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyclodextrins. Further modification of all 2-OH positions by etherification with iodo terminated triethylene glycol monomethyl ether (and tetraethylene glycol monomethyl ether, resp.) furnished water-soluble hosts. Especially the 灏?cyclodextrin derivatives exhibit very high binding potentials towards the anesthetic drugs sevoflurane and halothane. Since the resulting inclusion compounds are highly soluble in water at temperatures 閳?7 鎺矯 they are good candidates for new aqueous dosage forms which would avoid inhalation anesthesia. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Electric Literature of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Electric Literature of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma was written by Ghedira, Donia;Voissiere, Aurelien;Peyrode, Caroline;Kraiem, Jamil;Gerard, Yvain;Maubert, Elise;Vivier, Magali;Miot-Noirault, Elisabeth;Chezal, Jean-Michel;Farhat, Farhat;Weber, Valerie. And the article was included in European Journal of Medicinal Chemistry in 2018.SDS of cas: 954-81-4 This article mentions the following:

Due to an abundant chondrogenic, poorly vascularized and particularly hypoxic extracellular matrix, chondrosarcoma, a malignant cartilaginous tumor, is chemo- and radio-resistant. Surgical resection with wide margins remains the mainstay of treatment. To address the lack of therapy, our strategy aims to increase anticancer drugs targeting and delivery in the tumor, by leveraging specific chondrosarcoma hallmarks: an extensive cartilaginous extracellular matrix, namely the high neg. fixed charge d. and severe chronic hypoxia. A dual targeted therapy for chondrosarcoma was investigated by conjugation of a hypoxia-activated prodrug (HAP) to quaternary ammonium (QA) functions which exhibit a high affinity for polyanionic sites of proteoglycans (PGs), the major components of the chondrosarcoma extracellular matrix. Based on preclin. results, an imidazole prodrug, ICF05016, was identified and provided the basis for a lead optimization study. A series of 27 QA-phosphoramide mustard conjugates, differing by the type of QA function and the length of the alkyl linker, was yielded by a common multi-step sequence involving phosphorylation of a key 2-nitroimidazole alc. Then, a screening was realized by surface plasmon resonance technol. to assess biomol. interactions between QA derivatives and aggrecan, the most abundant PG in chondrosarcoma. Results revealed that affinity depends more on the type of QA function, than on the linker length. Moreover, the presence of a benzyl group enhanced affinity to aggrecan. Twelve compounds were shortlisted and evaluated for antiproliferative activity (i.e., growth inhibiting concentration 50), under normoxic and hypoxic conditions using the human extraskeletal myeloid chondrosarcoma cell line (HEMC-SS). For all prodrugs, hypoxic selectivity was maintained and even increased, compared with the lead. From this study, compound I emerged as the most effective PG-targeted HAPs with a dissociation constant of 2.10 娓璏 in the SPR experiment, a hypoxia cytotoxicity ratio of 24 and an efficient reductive cleavage under chem. and enzymic conditions. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4SDS of cas: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The kinetics of the reactions of picryl chloride with some substituted anilines. Part 6. 4-Substituted and 3,4-disubstituted anilines was written by Emokpae, Thomas A.;Eguavoen, Osa;Khalil-Ur-Rahman;Hirst, Jack. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1980.Safety of 3,4-Dibromoaniline This article mentions the following:

Arrhenius parameters were determined for the reactions of picryl chloride in MeCN with substituted anilines: 4-RC₆H₄NH₂ (R = F, Cl, Br, iodo, Me, OMe), 3,4-R₂C₆H₃NH₂ (R = Cl, Br, Me, OMe), 4,3-R(O₂N)C₆H₃NH₂ (R = F, Cl, Me), 3,4-R(MeO)C₆H₃NH₂ (R = F, Cl, Br, iodo), 3,4-F(O₂N)C₆H₃NH₂ and 3,4,5-(MeO)₃C₆H₂NH₂. In the 3,4-disubstituted series the effect of 2 Me groups on the free energy of activation is strictly additive, but for the rest the measured rate constants are greater than those calculated on the assumption of additivity. The results are rationalized in terms of the positions of the transition states on the reaction coordinate. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Safety of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Functionalized N-Heterocyclic Carbene Monolayers on Gold for Surface-Initiated Polymerizations was written by Choi, Yunsoo;Park, Chul Soon;Tran, Hung-Vu;Li, Chien-Hung;Crudden, Cathleen M.;Lee, T. Randall. And the article was included in ACS Applied Materials & Interfaces in 2022.COA of Formula: C15H29BrO2 This article mentions the following:

Although N-heterocyclic carbenes (NHCs) are superior to thiol adsorbates in that they form remarkably stable bonds with gold, the generation of NHC-based self-assembled monolayers (SAMs) typically requires a strong base and an inert atm., which limits the utility of such films in many applications. Herein, we report the development and use of bench-stable NHC adsorbates, benzimidazolium methanesulfonates, for the direct formation of NHC films on gold surfaces under an ambient atm. at room temperature without the need for extraordinary precautions. The generated NHC SAMs were fully characterized using ellipsometry, XPS, polarization modulation IR reflection-absorption spectroscopy (PM-IRRAS), and contact angle measurements, and they were compared to analogous SAMs generated from an NHC bicarbonate adsorbate. Based on these findings, a unique radical initiator 浼?锠?bidentate azo-terminated NHC adsorbate, NHC15AZO[OMs], was designed and synthesized for the preparation of SAMs on gold surfaces with both NHC headgroups bound to the surface. The adsorbate mols. in NHC15AZO SAMs can exist in a hairpin or a linear conformation depending on the concentration of the adsorbate solution used to prepare the SAM. These conformations were studied by a combination of ellipsometry, XPS, PM-IRRAS, and scanning tunneling microscopy using gold nanoparticles (AuNPs) as a tag material. Moreover, the potential utility of these unique radical-initiating NHC films as surface-initiated polymerization platforms was demonstrated by controlling the thickness of polystyrene brush films grown from azo-terminated NHC monolayer surfaces simply by adjusting the reaction time of the photoinitiated radical polymer growth process. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2COA of Formula: C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. COA of Formula: C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions was written by Youn, So Won;Kim, Young Ho;Jo, Yoon Hyung. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 192810-12-1 This article mentions the following:

A palladium-catalyzed aerobic C-H amidation of N-Ts-2-amino-3′-hydroxylbiaryls was developed to afford a diverse range of 1-hydroxycarbazoles with high regioselectivity and efficiency. This protocol benefits from operational simplicity, robustness, and sustainability using ambient air as the sole terminal oxidant. Further elaboration of the products obtained from this process provides facile access to various carbazole alkaloids including carbazolequinones and biscarbazoles. A mechanism involving dual directing group-assisted regioselective C-H activation at the more sterically hindered C2′-position of 2-amino-3′-hydroxylbiaryls is proposed. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Recommanded Product: 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mechanochemical Aliphatic Iodination (and Bromination) by Cascaded Cyclization was written by Bal, Ankita;Kumar Dinda, Tarun;Mal, Prasenjit. And the article was included in Asian Journal of Organic Chemistry in 2022.Category: bromides-buliding-blocks This article mentions the following:

Herein, the synthesis of oxazoline derivatives I [Ar = Ph, 4-MeC₆H₄, 3-BrC₆H₄, etc.] from N-allyl benzamides via mechanochem. cascaded cyclization and halogenation using N-iodo- and N-bromosuccinimides, resp., as bifunctional reagents was demonstrated. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Azide-Modified Membrane Lipids: Synthesis, Properties, and Reactivity was written by Lindner, Sindy;Gruhle, Kai;Schmidt, Rico;Garamus, Vasil M.;Ramsbeck, Daniel;Hause, Gerd;Meister, Annette;Sinz, Andrea;Drescher, Simon. And the article was included in Langmuir in 2017.Computed Properties of C15H29BrO2 This article mentions the following:

In the present work, we describe the synthesis and the temperature-dependent behavior of photoreactive membrane lipids as well as their capability to study peptide-lipid interactions. The modified phospholipids contained an azide group either in the middle part or at the end of an alkyl chain and also differed in the linkage (ester vs. ether) of the 2nd alkyl chain. The temperature-dependent aggregation behavior of the azidolipids was studied using differential scanning calorimetry (DSC), FTIR spectroscopy, and SAXS. Aggregate structures were visualized by stain and cryo-transmission electron microscopy (TEM) and were further characterized by dynamic light scattering (DLS). We showed that the position of the azide group and the type of linkage of the alkyl chain at the sn-2 position of the glycerol influenced the type of aggregates formed as well as their long-term stability: azidolipids P10AzSPC and r12AzSHPC showed the formation of extrudable liposomes, which were stable in size during storage. In contrast, azidolipids that carry a terminal azido moiety either formed extrudable liposomes, which showed time-dependent vesicle fusion (P15AzPdPC), or self-assembled in large sheet-like, non-extrudable aggregates (r15AzPdHPC) where the lipid mols. were arranged in an interdigitated orientation at temperatures below the T_m (L_{灏?/sub>I phase). Finally, a P10AzSPC:DMPC mixture was used for photochem.-induced crosslinking experiments with a transmembrane peptide (WAL-peptide) to demonstrate the applicability of the azidolipids for the anal. of peptide/lipid interactions. The efficiency of photocrosslinking was monitored by attenuated total reflection IR spectroscopy and mass spectrometry. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Computed Properties of C15H29BrO2).}

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary