Month: February 2023

Access to Planar Chiral Ferrocenes via N-Heterocyclic Carbene-Catalyzed Enantioselective Desymmetrization Reactions was written by Lv, Xiaokang;Xu, Jun;Sun, Cuiyun;Su, Fen;Cai, Yuanlin;Jin, Zhichao;Chi, Yonggui Robin. And the article was included in ACS Catalysis in 2022.Application of 28322-40-9 This article mentions the following:

Ferrocene-derived dicarbaldehydes bearing pro-chiral planes are desymmetrized under the catalysis of chiral N-heterocyclic carbene organic catalysts. The reaction features selective activation and reaction of one of the aldehyde moieties of the ferrocene derivative while leaving the other aldehyde unit untouched. The authors’ reaction affords enantiomerically enriched planar chiral ferrocene products obtained that are amenable for further transformations. Preliminary application studies show encouraging results when the authors’ products are explored for catalysis in chem. synthesis and for antimicrobial utilities in pesticide development. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Application of 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Construction of Chiral 2-Substituted Octahydroindoles from Cyclic Ketones and Nitroolefins Bearing only One 浼?Substituent was written by Han, Yong;Zheng, Bo;Peng, Yungui. And the article was included in Advanced Synthesis & Catalysis in 2015.Computed Properties of C9H11BrO This article mentions the following:

A dual catalytic system was developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitroolefins bearing only one 浼?substituent. The resulting 绾?nitro ketones, which contain a substituent on the carbon connected to the nitro group, were formed in excellent yields (>80%) with high levels of stereoselectivity (up to 94:6 dr and 98% ee) when the reaction was performed in benzene at 0鎺?with 10 mol% of the optimal amine/phosphoric acid combination (1:1) as a catalyst. Subsequent reduction of the nitro group followed by intramol. reductive amination afforded optically active cis-octahydroindole analogs bearing a non-functional substituent at their 2-position. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Pharmacological Evaluation of Fused 灏?Homophenylalanine Derivatives as Potent DPP-4 Inhibitors was written by Jiang, Tao;Zhou, Yuren;Chen, Zhuxi;Sun, Peng;Zhu, Jianming;Zhang, Qiang;Wang, Zhen;Shao, Qiang;Jiang, Xiangrui;Li, Bo;Chen, Kaixian;Jiang, Hualiang;Wang, Heyao;Zhu, Weiliang;Shen, Jingshan. And the article was included in ACS Medicinal Chemistry Letters in 2015.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene This article mentions the following:

Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused 灏?homophenylalanine derivatives as novel DPP-4 inhibitors was designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents was written by Rai, Ganesha;Thomas, Craig J.;Leister, William;Maloney, David J.. And the article was included in Tetrahedron Letters in 2009.Electric Literature of C9H6BrFO2 This article mentions the following:

The synthesis of a series of 4,5-disubstituted furoxans, 1,2,5-oxadiazole-2-oxides I (e.g., R¹ = 4-F, 3-CF₃, etc) was described. These compounds were prepared in an effort to probe the SAR around the Ph substituent and oxadiazole core for studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1Electric Literature of C9H6BrFO2).

3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Electric Literature of C9H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Electroreductive Syntheses of Triphenylenes Using ortho-Dihalobenzene-Derived Benzynes was written by Li, Zhao-Ming;Shuai, Bin;Ma, Cong;Fang, Ping;Mei, Tian-Sheng. And the article was included in Chinese Journal of Chemistry in 2022.HPLC of Formula: 615-55-4 This article mentions the following:

Electrochem. nickel-catalyzed syntheses of triphenylenes e.g., I, by a reductive trimerization of ortho-dibromobenzenes e.g.., 5,6-dibromoindane or ortho-bromoarylsulfurofluoridates e.g., 2-bromo-4-fluorophenyl sulfurofluoridate, or by reductive cross-coupling of ortho-dibromobenzenes to 2,2′-diiodobiphenyls, were described. The former provides a practical means for the construction of triphenylene derivatives e.g., ,I in up to 87% isolated yield at room temperature For 1,2-dihalo-3-methylbenzenes and related ortho-trisubstituted substrates, trimerizations proceed with high substrate-controlled regioselectivity for the non-C3h sym. triphenylene isomer. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4HPLC of Formula: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices was written by Wang, Kai;Zhang, Ruixiao;Yue, Xinmin;Zhou, Zheng;Bai, Lihuan;Tong, Yue;Wang, Bei;Gu, Dening;Wang, Shuo;Qiao, Yanqi;Liu, Qian;Xue, Xue;Yin, Yongmei;Xi, Rimo;Meng, Meng. And the article was included in ACS Sensors in 2021.HPLC of Formula: 166821-88-1 This article mentions the following:

Reliable and accurate glucose detection in biol. samples is of great importance in clin. diagnosis and medical research. Chem. probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has shown potential in glucose probing because of its high sensitivity. However, poor solubility limits its applications in aqueous media. In this work, we systemically modify P-DBA by introducing fluoro (F-), chloro (Cl-), methoxyl (MeO-), or cyano (CN-) substituents. Among these probes, the cyano-substituted probe (CN-DBA) displays the highest glucose-binding constant (6489.5 M^-1, 33% MeOH). More importantly, it shows good water solubility in the aqueous solution (0.5% MeOH), with ultrasensitive recognition with glucose (LOD = 1.51 娓璏) and robust sensing from pH 6.0 to 9.0. Based on these features, the CN-DBA is finally applied to detect glucose in cell lysates and plasma, with satisfactory recovery and precision. These results demonstrate that CN-DBA could serve as an accurate, sensitive fluorescent probe for glucose assays in biol. samples. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1HPLC of Formula: 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cationic 灏?cyclodextrin derivative for chiral separations was written by Haynes, Judson L. III;Shamsi, Shahab A.;O’Keefe, Frank;Darcey, Raphel;Warner, Isiah M.. And the article was included in Journal of Chromatography A in 1998.Product Details of 53784-83-1 This article mentions the following:

A novel hepta-substituted 灏?cyclodextrin bearing the methoxyethylamine group linked to the upper cyclodextrin rim was successfully used as a chiral selector for enantiomeric separation of nonsteroidal anti-inflammatory drugs (NSAIDs) and phenoxypropionic acid herbicides (PPAHs). Separation parameters such as pH and concentration have major influences on enantiomeric resolution of the NSAIDs and PPAHs. Heptakis(6-methoxyethylamine-6-deoxy)-灏?cyclodextrin [灏?CD-OMe (VII)] performs exceptionally well for the enantiomeric resolution of NSAIDs: indoprofen and fenoprofen (R_s = 11 and 14, resp.). Baseline enantiomeric separation of a mixture of six pairs of PPAHs was achieved in under 30 min. Compared to other cationic 灏?cyclodextrins reported in the literature, the 灏?CD-OMe (VII) showed improved selectivity for both classes of the aforementioned anionic racemates. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Product Details of 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides with spiro-bidentate-pyox ligands was written by Gao, Nanxing;Li, Yanshun;Cao, Guorui;Teng, Dawei. And the article was included in New Journal of Chemistry in 2021.Category: bromides-buliding-blocks This article mentions the following:

The cross-electrophile coupling of aryl bromides RBr [R = Ph, 4-(ethoxycarbonyl)phenyl, 1-(1H-indol-1-yl)ethan-1-one, etc.] and cyclic secondary alkyl bromides I [R¹ = ethoxycarbonyl, (benzyloxy)carbonyl, (4-methylbenzene)sulfonyl, etc., X = (CH₂)_n, n = 1, 2] catalyzed by nickel/spiro-bidentate-pyox ligands, e.g., II, with lithium chloride as the additive for the Csp²-Csp³ bond formation is reported. The reaction could tolerate functional groups such as sulfonamide, ester, aldehyde, ketone, protected indolyl, tert-butoxycarbonyl, aryl nitriles and aryl chloride. Various aryl-cyclic secondary alkyl Csp²-Csp³ bond products, e.g., III, were synthesized under optimal reaction conditions (19 examples). In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Category: bromides-buliding-blocks).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

1-Ethoxy-3-trifluoromethyl-1,3-butadiene and congeners as Diels-Alder components opening an entry to functionalized (trifluoromethyl)benzenes and -pyridines was written by Volle, Jean-Noel;Schlosser, Manfred. And the article was included in European Journal of Organic Chemistry in 2002.Related Products of 107317-58-8 This article mentions the following:

1-Ethoxy-3-trifluoromethyl-1,3-butadiene and its 2-bromo- and 2-phenyl-substituted derivatives have been prepared by Wittig methylenation of the corresponding 4-ethoxy-1,1,1-trifluoro-3-buten-2-ones, which in turn are readily accessible from trifluoroacetic acid. The electron-rich/electron-poor dienes combine smoothly with di-Me acetylenedicarboxylate and Me propiolate to provide trifluoromethyl-substituted phthalates or benzoates. Satisfactory yields of 4-(trifluoromethyl)pyridinecarboxylic acids can even be achieved with Me cyanoformate, a less reactive dienophile, if a large excess of the dienophile is employed. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8Related Products of 107317-58-8).

Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 107317-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular palladium(II)/(IV) catalysed C(sp³)-H arylation of tertiary aldehydes using a transient imine directing group was written by St John-Campbell, Sahra;Bull, James A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Related Products of 61150-57-0 This article mentions the following:

Palladium catalyzed 灏?C(sp³)-H activation of tertiary aldehydes RCH₂C(R₁)(R₂)CHO [R = 2-Br-5-ClC₆H₃, 2-IC₆H₄, 2-Br-4-H₃COC₆H₃, etc.; R₁ = Me, Et, n-Pr; R₂ = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R₄ = H, 5-F, 4-Cl, 5-CF₃, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary