Month: February 2023

N-Phthalimidoalkyl derivatives of 2灏?carbomethoxy-3灏?(4′-iodophenyl)tropane (灏?CIT): brain monoamine transporter affinity was written by Tamagnan, Gilles;Neumeyer, John L.;Gao, Yigong;Wang, Shaoyin;Kula Nora;Baldessarini, Ross J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1997.Recommanded Product: N-(5-Bromopentyl)phthalimide This article mentions the following:

A series of novel N-phthalimidoalkyl analogs I (n = 2-5, 8) for the stable phenyltropane 灏?CIT were synthesized and evaluated by selective radioligand binding assays for affinity to transporters for dopamine (DA), serotonin (5-HT) and norepinephrine (NE) in corpus striatum tissue from rat forebrain. 灏?CIT and I (n = 4, 5, 8) showed similarly greater affinity at 5-HT than DA transporters; this affinity was lost with I (n = 2, 3). These results are consistent with interference at a critical binding site for the tropane nitrogen on the transporter proteins and indicate that the tropane nitrogen atom can be substituted with large substituted alkyl moieties without loss of affinity or selectivity for amine transporters. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Isomeric thermally activated delayed fluorescence emitters based on a quinolino[3,2,1-de]acridine-5,9-dione multiple resonance core and carbazole substituent was written by Liu, Jing-Feng;Zou, Sheng-Nan;Chen, Xing;Yang, Sheng-Yi;Yu, You-Jun;Fung, Man-Keung;Jiang, Zuo-Quan;Liao, Liang-Sheng. And the article was included in Materials Chemistry Frontiers in 2022.Related Products of 100189-84-2 This article mentions the following:

The color purity of the pixels is an essential indicator in organic light-emitting diode (OLED) com. displays. Since the two important parameters of high color purity and efficiency can be achieved simultaneously, multiple resonance thermally activated delayed fluorescence (MR-TADF) emitters have achieved rapid development. Recently, there has been a lot of research work on connecting various donor (D) moieties to the existing MR core, but few studies on how the linking moiety affects the efficiency of MR-TADF emitters. To figure out the influence of substituents on the MR-TADF system, we developed three isomers QAOCz1, QAOCz2, and QAOCz3, which are constructed with the same moieties of 3,11-diphenylquinolino[3,2,1-de]acridine-5,9-dione and 9-phenyl-9H-carbazole (PhCz) by different site connections. Through reasonable adjustments of the substitution site, the donor-acceptor (D-A) interaction of the isomers gradually weakened and mol. rigidity gradually increased. As a result, their singlet-triplet energy gap (铻朎ST) gradually decreased and their photoluminescence quantum yield (PLQY) gradually rose. QAOCz3 with the weakest D-A interaction successfully achieves a much higher PLQY of 98.9% and a smaller 铻朎ST of 0.16 eV. The QAOCz3 based OLED not only realizes the best maximum external quantum efficiency (EQE) of 21.1% but also has the narrowest full-width at half maximum (FWHM) of 40 nm. This work shows that weakening the D-A interaction between the substituents and the MR core by a spacer group is of great significance for the construction of efficient MR-TADF emitters. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Related Products of 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Formal Dehydration Polymerization of Propargylic Alcohols via Cumulene Intermediates was written by Wu, Bin;Su, Hao-Ze;Wang, Zi-Yuan;Yu, Zi-Di;Sun, Han-Li;Yang, Fan;Dou, Jin-Hu;Zhu, Rong. And the article was included in Journal of the American Chemical Society in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

Here we report a copper-catalyzed formal dehydration polymerization of propargylic alcs. Copper catalysis allows for efficient in situ generation of [n]cumulenes (n = 3, 5) by a soft deprotonation/灏?elimination pathway and subsequent polymerization via organocopper species. Alkyne polymers (M_n up to 36.2 kg/mol) were produced with high efficiency (up to 95% yield) and excellent functional group tolerance. One-pot synthesis of semiconducting head-to-head poly(phenylacetylene) was demonstrated through a polymerization-isomerization sequence. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO₂F₂) as fluoride provider was written by Song, Xuyan;He, Yunlu;Wang, Bo;Peng, Sanwen;Pan, Xi;Wei, Min;Liu, Qiang;Qin, Hua-Li;Tang, Haolin. And the article was included in Tetrahedron in 2022.Product Details of 454-65-9 This article mentions the following:

A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO₂F [Ar = 4-MeC₆H₄, 4-PhC₆H₄, 4-ClC₆H₄, etc.] was developed from aryl sulfonyl chlorides using SO₂F₂ as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9Product Details of 454-65-9).

3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 454-65-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D₃ Receptor Subtype was written by Robarge, Michael J.;Husbands, Stephen M.;Kieltyka, Andrzej;Brodbeck, Robbin;Thurkauf, Andrew;Newman, Amy Hauck. And the article was included in Journal of Medicinal Chemistry in 2001.HPLC of Formula: 954-81-4 This article mentions the following:

The dopamine D₃ receptor subtype has been recently targeted as a potential neurochem. modulator of the behavioral actions of psychomotor stimulants, such as cocaine. However, definitive behavioral investigations have been hampered by the lack of highly selective D₃ agonists and antagonists. In an attempt to design a novel class of D₃ ligands with which to study this receptor system, a series of chem. divergent compounds that possessed various structural features that exist within several classes of reputed D₃ agents was screened and compared to the recently reported NGB 2904. On the basis of these results, a novel series of compounds was designed that included functional moieties that were required for high-affinity and selective binding to D₃ receptors. All the compounds in this series included an aryl-substituted piperazine ring, a varying alkyl chain linker (C₃-C₅), and a terminal aryl amide. The compounds were synthesized and evaluated in vitro for binding in CHO cells transfected with human D₂, D₃, or D₄ receptor cDNAs. D₃ binding affinities ranged from K_i = 1.4 to 1460 nM. The most potent analog in this series, I, demonstrated a D₃/D₂ selectivity of 64 and a D₃/D₄ selectivity of 1300. Structure-activity relationships for this class of ligands at D₃ receptors will provide new leads toward the development of highly selective and potent mol. probes that will prove useful in the elucidation of the role D₃ receptors play in the psychomotor stimulant and reinforcing properties of cocaine. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4HPLC of Formula: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A highly practical and convenient halogenation of fused heterocyclic N-oxides was written by Wang, Dong;Wang, Yuxi;Zhao, Junjie;Li, Linna;Miao, Longfei;Wang, Dong;Sun, Hua;Yu, Peng. And the article was included in Tetrahedron in 2016.Synthetic Route of C12H7BrN2 This article mentions the following:

A novel, simple and practical method for the regioselective halogenation of fused heterocyclic N-oxides was developed. It employs Vilsmeier reagent, generated in situ by POX₃ and DMF, as both the activating agent and the nucleophilic halide source. The method is amenable across a broad range of substrates, including quinolines, isoquinolines and the diazine N-oxides, possessing a variety of substitution patterns. Furthermore, all of the reagents associated are cheap and easy to obtain. The potential extension of this method to a one-pot oxidation/halogenation sequence that obviates the need for isolation of the N-oxide intermediates is also presented. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Synthetic Route of C12H7BrN2).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C12H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Evidence of an Odorant-Binding Protein in the Human Olfactory Mucus: Location, Structural Characterization, and Odorant-Binding Properties was written by Briand, Loiec;Eloit, Corinne;Nespoulous, Claude;Bezirard, Valerie;Huet, Jean-Claude;Henry, Celine;Blon, Florence;Trotier, Didier;Pernollet, Jean-Claude. And the article was included in Biochemistry in 2002.Computed Properties of C15H29BrO2 This article mentions the following:

Odorant-binding proteins (OBPs) are small abundant extracellular proteins belonging to the lipocalin superfamily. They are thought to participate in perireceptor events of odor detection by carrying, deactivating, and/or selecting odorant mols. Putative human OBP genes (hOBP) have recently been described [Lacazette et al. (2000) Hum. Mol. Genet. 9, 289-301], but the presence of the corresponding proteins remained to be established in the human olfactory mucus. This paper reports the first evidence of such expression in the mucus covering the olfactory cleft, where the sensory olfactory epithelium is located. On the contrary, hOBPs were not observed in the nasal mucus covering the septum and the lower turbinate. To demonstrate the odorant binding activity of these proteins, a corresponding recombinant protein variant, hOBP_{IIa浼?/sub>, was secreted by the yeast Pichia pastoris and thoroughly characterized. It appears as a monomer with one disulfide bond located between C59 and C151, a conservative feature of all other vertebrate OBPs. By measuring the displacement of several fluorescent probes, we show that hOBPIIa浼?/sub> is able to bind numerous odorants of diverse chem. structures, with a higher affinity for aldehydes and large fatty acids. A computed 3D model of hOBPIIa浼?/sub> is proposed and reveals that two lysyl residues of the binding pocket may account for the increased affinity for aldehydes. The relatively limited specificity of hOBPIIa浼?/sub> suggests that other human OBPs are expected to take into account the large diversity of odorant mols. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Computed Properties of C15H29BrO2).}

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of phthalonitriles using a palladium catalyst was written by Iqbal, Zafar;Lyubimtsev, Alexey;Hanack, Michael. And the article was included in Synlett in 2008.Formula: C6H5Br2N This article mentions the following:

An easy synthetic method to obtain phthalonitriles from o-dibromobenzenes under mild conditions in high yields using Zn(CN)₂ and a catalytic amount of tris(dibenzylideneacetone)dipalladium and 1,1′-bis(diphenylphosphino)ferrocene is described. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Formula: C6H5Br2N).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schiff bases formed between pyridoxal 5′-phosphate and amino-灏?cyclodextrins: intramolecular remote ion pair interactions of the phosphate with ammonium moieties was written by Tamagaki, Seizo;Takahashi, Masahiko;Kanamori, Junji;Tagaki, Waichiro. And the article was included in Supramolecular Chemistry in 1994.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

Equilibrium involved in the Schiff base formations of pyridoxal 5′-phosphate (PLP) and 5′-deoxypyridoxal with mono-, di-, and peraminocyclodextrins have been studied to determine equilibrium binding constants in aqueous media at several pH values. These results, as well as the CD study, show that remote electrostatic interactions between the neg. charged 5′-phosphate group and a second ammonium group on the cyclodextrins play a significant role in the complexation. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine was written by Staron, Jakub;Pietrus, Wojciech;Bugno, Ryszard;Kurczab, Rafal;Satala, Grzegorz;Warszycki, Dawid;Lenda, Tomasz;Wantuch, Anna;Hogendorf, Adam S.;Hogendorf, Agata;Duszynska, Beata;Bojarski, Andrzej J.. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 4457-67-4 This article mentions the following:

To elucidate the role of halogen atoms in the binding of SSRIs to SERT, a series of 22 fluoxetine and fluvoxamine analogs substituted with fluorine, chlorine, bromine, and iodine atoms, differently arranged on the Ph ring was designed. The obtained biol. activity data, supported by a thorough in silico binding mode anal., allowed the identification of two partners for halogen bond interactions: the backbone carbonyl oxygen atoms of E493 and T497. Addnl., compounds with heavier halogen atoms were found to bind with the SERT via a distinctly different binding mode, a result not presented elsewhere. The subsequent anal. of the prepared XSAR sets showed that E493 and T497 participated in the largest number of formed halogen bonds. The XSAR library anal. led to the synthesis of two of the most active compounds (3,4-diCl-fluoxetine, SERT K_i = 5 nM and 3,4-diCl-fluvoxamine, SERT K_i = 9 nM, fluoxetine SERT K_i = 31 nM, fluvoxamine SERT K_i = 458 nM). An example of the successful use of a rational methodol. was presented to analyze binding and design more active compounds by halogen atom introduction. ‘XSAR library anal.’, a new tool in medicinal chem., was instrumental in identifying optimal halogen atom substitution. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary