Month: February 2023

Carbonylation of bromo(bromomethyl)benzenes to alkyl carboalkoxyphenylacetates catalyzed by cobalt carbonyl was written by Shim, Sang Chul;Doh, Chil Hoon;Lee, Dong Yub;Youn, Young Zoo;Lee, Seung Yub;Chae, Shin Ae;Oh, Dae Hee;Oh, Hunseung. And the article was included in Bulletin of the Korean Chemical Society in 1992.Synthetic Route of C10H11BrO2 This article mentions the following:

Carbonylation of bromo(bromomethyl)benzene catalyzed by cobalt carbonyl gave (alkoxycarbonyl)phenylacetates. Carbonylation of 1-bromo-4-(bromomethyl)benzene with CO/Co₂(CO)₈/EtOH/MeI gave 98% Et [4-(ethoxycarbonyl)phenyl]acetate. The effects of base and alcs. in this reaction were examined In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Synthetic Route of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Synthetic Route of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Building fluorescent sensors by template polymerization: the preparation of a fluorescent sensor for D-fructose was written by Wang, Wei;Gao, Shouhai;Wang, Binghe. And the article was included in Organic Letters in 1999.Product Details of 166821-88-1 This article mentions the following:

The application of mol. imprinting in making fluorescent sensors was hampered by the lack of suitable fluorescent tags, which would respond to the binding event with significant fluorescence intensity changes. The authors have designed and synthesized a fluorescent monomer which allows for the preparation of fluorescent sensors of cis diols using mol. imprinting methods. This monomer was used for the preparation of sensitive fluorescent sensors for D-fructose. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Product Details of 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Graphene Oxide-Supported Hypervalent Organoiodine (III): Recyclable Reagent for Selective and Metal-Free Oxidation of Alcohols was written by Ghanbari, Nastaran;Ghafuri, Hossein;Zand, Hamid Reza Esmaili. And the article was included in ChemistrySelect in 2018.Electric Literature of C7H7BrO2 This article mentions the following:

In this research, main emphasis has been placed on the oxidizing properties of graphene oxide (GO) and hypervalent organoiodine (III) (HVI) and their oxidizing effect in GO-HVI. GO-HVI as a metal-free, environmentally-friendly, recyclable and efficient heterogeneous reagent was synthesized and completely characterized by Fourier transform IR spectroscopy (FT-IR), energy dispersive X-ray (EDX), field emission SEM (FE-SEM), X-ray diffraction, and at. force microscopy (AFM). The synthesized GO-HVI was used to achieve an effective and selective method for oxidation of various alcs. All substituted alcs. were oxidized in good to excellent yields under mild conditions at room temperature The oxidizing ability of GO-HVI was higher in comparison with starting GO and HVI. This GO-HVI have great stability and could be recycled six times without noteworthy loss of activity. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-(hydroxymethyl)phenol (cas: 170434-11-4Electric Literature of C7H7BrO2).

5-Bromo-2-(hydroxymethyl)phenol (cas: 170434-11-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C7H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Asymmetric Michael addition catalyzed by D-glucose-based azacrown ethers was written by Novak, Tibor;Tatai, Janos;Bako, Peter;Czugler, Matyas;Keglevich, Gyorgy;Toke, Laszlo. And the article was included in Synlett in 2001.Formula: C13H14BrNO2 This article mentions the following:

Novel sugar-based azacrown ethers with phosphinoxidoalkyl side-chain were synthesized. They show asym. induction as phase-transfer catalysts in the Michael addition of 2-nitropropane to chalcone (95% ee) and to 3-fur-2-yl-1-phenyl-2-propen-1-one (80% ee). In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Formula: C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis and insecticide activity of novel acetylcholinesterase inhibitors: triazolinone and phthalimide heterodimers was written by Xie, Ruliang;Mei, Xiangdong;Ning, Jun. And the article was included in Chemical & Pharmaceutical Bulletin in 2019.COA of Formula: C13H14BrNO2 This article mentions the following:

A new series of 1,2,4-triazolin-3-one and phthalimide heterodimers I [X = (CH₂)_n; n = 1, 2, 9, etc.] was synthesized and evaluated for their insecticidal and acetylcholinesterase inhibitory activities. Most of the synthesized compounds I showed good in vitro inhibitory activities against both Drosophila melanogaster acetylcholinesterase (DmAChE) and Musca domestica acetylcholinesterase (MdAChE). Among them, compound I (n = 7) was found to be most potent AChE inhibitor (IC₅₀ = 8.07 μM to DmAChE, IC₅₀ = 32.24 μM to MdAChE), whose activities were 2.31- and 1.35-fold more active than the pos. control ethion (CP, IC₅₀ = 18.62 μM to DmAChE, IC₅₀ = 43.56 μM to MdAChE). The docking model study revealed that compound I (n = 7) possessed fitted spatial structure and bound to central pocket and peripheral site of DmAChE. Moreover, most of the compounds I demonstrated high insecticidal activity to Lipaphis erysimi and Tetranychus cinnabarinus at concentration of 300 mg/L. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4COA of Formula: C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl Azides as Radical Acceptors in the Vitamin B₁₂-Catalyzed Synthesis of Unsymmetrical Ketones was written by Dworakowski, Krzysztof R.;Pisarek, Sabina;Hassan, Sidra;Gryko, Dorota. And the article was included in Organic Letters in 2021.HPLC of Formula: 57293-19-3 This article mentions the following:

Vitamin B₁₂ catalyzed the reaction of vinyl azides with electrophiles under light irradiation to afforded unsym. carbonyl compounds R¹C(O)CH₂R² [R¹ = Ph, 4-t-BuC₆H₄, 4-ClC₆H₄, etc.; R² = (CH₂)₃CN, (CH₂)₃Ph, (CH₂)₃C(O)OEt, etc.] in decent yields. Mechanistic studies revealed that alkyl radicals were key intermediates in this transformation. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of cadiolide analogues as inhibitors of bacterial biofilm formation was written by Mairink, Simone Z.;Barbosa, Luiz C. A.;Boukouvalas, John;Pedroso, Silvia H. S. P.;Santos, Simone G.;Magalhaes, Paula P.;Farias, Luiz M.. And the article was included in Medicinal Chemistry Research in 2018.Computed Properties of C8H6Br2O2 This article mentions the following:

Bacterial biofilm infections pose a major clin. challenge due to the ability of biofilms to resist high levels of conventional antibiotics. In the present study, we describe the synthesis and biofilm inhibiting properties of nine new butenolides related to the cadiolide family of marine antibiotics. Eight new cadiolide analogs were synthesized using oxazole-ynone Diels-Alder cycloaddition/cycloreversion as the key step. Their effects on bacterial growth and biofilm formation were investigated against a range of Gram-pos. and Gram-neg. bacteria, namely Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. The cadiolide analogs strongly inhibited biofilm formation of the two Gram-pos. bacteria (S. aureus and E. faecalis) at concentrations as low as 0.3 μg mL^-1 and 0.5 μg mL^-1, resp. The identification of synthetic cadiolides with potent biofilm-inhibiting capabilities opens a new avenue for therapeutic interventions and highlights the potential of this class of compounds for antimicrobial drug development. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Computed Properties of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa was written by Batt, Douglas G.;Qiao, Jennifer X.;Modi, Dilip P.;Houghton, Gregory C.;Pierson, Deborah A.;Rossi, Karen A.;Luettgen, Joseph M.;Knabb, Robert M.;Jadhav, P. K.;Wexler, Ruth R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Application of 6515-58-8 This article mentions the following:

Structural features of the 5-amidinoindole inhibitor I of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa. Several analogs of I with greatly diminished factor Xa selectivity were prepared and the structural features favorable for factor IXa activity were identified. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Application of 6515-58-8).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 6515-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives was written by Muimhneachain, Eoin O.;Pardo, Leticia M.;Bateman, Lorraine M.;Rao Khandavilli, U. B.;Lawrence, Simon E.;McGlacken, Gerard P.. And the article was included in Advanced Synthesis & Catalysis in 2017.HPLC of Formula: 61150-57-0 This article mentions the following:

A synthesis of tricyclic oxoisochromene derivatives via an intramol. direct arylation of cycloalkyl-1,3-diketone-derived α,β-unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0HPLC of Formula: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The bromination of the silver salts of organic acids in trichloroethylene was written by Stoll, M.;Rouve, A.. And the article was included in Helvetica Chimica Acta in 1951.Name: 15-Bromopentadecanoic acid This article mentions the following:

Formation of bromides from Ag salts and Br goes best in solvents which react with Br. Ag mono-Me thapsate treated with Br in CCl₄ gives 65-75% Me 15-bromopentadecanoate and 18-25% free acid. When the reaction is carried out under N in C₂HCl₃ the yield is 78-85%, with 9-11% free acid and about 8% of a neutral compound b¹⁵ 90-5°. The solvent probably takes part in the reaction. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Name: 15-Bromopentadecanoic acid).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 15-Bromopentadecanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary