Month: February 2023

Design, synthesis, and structure-activity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates was written by Cao, Xufeng;Xu, Yuanyuan;Cao, Yongbing;Wang, Ruilian;Zhou, Ran;Chu, Wenjing;Yang, Yushe. And the article was included in European Journal of Medicinal Chemistry in 2015.Product Details of 38239-45-1 This article mentions the following:

In order to further enhance the anti-Aspergillus efficacy of our previously discovered antifungal lead compounds, two series of novel azoles I [ R¹ = Ph, 4-pyridyl, 2-CN-5-pyridyl, etc.]and II [R¹ = Ph, 4-Me-C₆H₄, 4-F-C₆H₄, etc.], featuring thieno[2,3-c]pyrrolidone and thieno[3,2-c]pyrrolidone nuclei were designed and evaluated for their in vitro activity on the basis of the binding mode of albaconazole using mol. docking, along with SARs of antifungal triazoles. Most of target compounds exhibited excellent activity against Candida and Cryptococcus spp., with MIC values in the range of 0.0625 婵炴挾鎸?mL to 0.0156 婵炴挾鎸?mL. The thieno[3,2-c]pyrrolidone unit was more suited for improving activity against Aspergillus spp. The most potent compound, II [R¹ = Br], was selected for further development due to its significant in vitro activity against Aspergillus spp. (MIC = 0.25 婵炴挾鎸?mL), as well as its high metabolic stability in human liver microsomes. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1Product Details of 38239-45-1).

5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Product Details of 38239-45-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stacked Reticular Frame Boosted Circularly Polarized Luminescence of Chiral Covalent Organic Frameworks was written by Du, Cong;Zhu, Xuefeng;Yang, Chenchen;Liu, Minghua. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Chiral covalent organic frameworks (COFs) with circularly polarized luminescence (CPL) are intriguing as advanced chiroptical materials but have not been reported to date. We constructed chiroptical COF materials with CPL activity through the convenient Knoevenagel condensation of formyl-functionalized axially chiral linkers and C3-sym. 1,3,5-benzenetriacetonitrile. Remarkably, the as-prepared chiral COFs showed high absorption and luminescent dissym. factors up to 0.02 (g_abs) and 0.04 (g_lum), resp. In contrast, the branched chiral polymers from the same starting monomers were CPL silent. Structural and spectral characterization revealed that the reticular frame was indispensable for CPL generation via confined chirality transfer. Moreover, reticular stacking boosted the CPL performance significantly due to the interlayer restriction of frame. This work demonstrates the first example of a CPL-active COF and provides insight into CPL generation through covalent reticular chem., which will play a constructive role in the future design of high-performance CPL materials. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Safety of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hydrogen-bonded banana liquid crystals was written by Gimeno, Nelida;Ros, Maria Blanca;Serrano, Jose Luis;de la Fuente, Maria Rosario. And the article was included in Angewandte Chemie, International Edition in 2004.Electric Literature of C8H7BrO2 This article mentions the following:

H-bonded bent complexes of benzoic acids (H donor) and nonmesomorphic V-shaped 4′-stilbazoles (H acceptor) give rise to polar smectic C (SmCP) mesophases. The multifunctional character of these noncovalent materials is confirmed through their electrooptical, dielec., and luminescent responses. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Electric Literature of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of lipophilic bisanthracene fluorophores: versatile building blocks toward the synthesis of new light-harvesting dendrimers was written by Takahashi, Masaki;Yamamoto, Ayato;Inuzuka, Toshiyasu;Sengoku, Tetsuya;Yoda, Hidemi. And the article was included in Tetrahedron in 2011.Synthetic Route of C8H6Br2O2 This article mentions the following:

Lipophilic bisanthracene-based fluorophore and its derivatives were synthesized by the Suzuki-Miyaura cross-coupling reaction of 9-anthrylboronic acid with a substituted dibromobenzene. In addition to desirable fluorescent properties, these mol. systems were demonstrated to serve as versatile building blocks toward the synthesis of two types of new light-harvesting dendrimers due to their chem. stability. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Synthetic Route of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors was written by Cowen, Scott D.;Russell, Daniel;Dakin, Leslie A.;Chen, Huawei;Larsen, Nicholas A.;Godin, Robert;Throner, Scott;Zheng, Xiaolan;Molina, Audrey;Wu, Jiaquan;Cheung, Tony;Howard, Tina;Garcia-Arenas, Renee;Keen, Nicholas;Pendleton, Christopher S.;Pietenpol, Jennifer A.;Ferguson, Andrew D.. And the article was included in Journal of Medicinal Chemistry in 2016.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Protein lysine methyltransferases (KMTs) have emerged as important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor Me groups from the cofactor S-adenosylmethionine to specific acceptor lysine residues on histones, leading to changes in chromatin structure and transcriptional regulation. These enzymes also methylate an array of non-histone proteins, suggesting addnl. mechanisms by which they influence cellular physiol. SMYD2 is reported to be an oncogenic methyltransferase that represses the functional activity of the tumor suppressor proteins p53 and RB. HTS screening led to identification of five distinct substrate-competitive chem. series, e.g., I (X = C, R¹ = H, CN, OMe; X = N, R¹ = H, OMe, NHMe). Determination of liganded crystal structures of SMYD2 contributed significantly to ‘hit-to-lead’ design efforts, culminating in the creation of potent and selective inhibitors that were used to understand the functional consequences of SMYD2 inhibition. Taken together these results have broad implications for inhibitor design against KMTs, and clearly demonstrate the potential for developing novel therapies against these enzymes. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of quinoline-based NNN-pincer nickel(II) Complexes: a robust and improved catalyst system for C-H bond alkylation of azoles with alkyl halides was written by Patel, Ulhas N.;Pandey, Dilip K.;Gonnade, Rajesh G.;Punji, Benudhar. And the article was included in Organometallics in 2016.HPLC of Formula: 57293-19-3 This article mentions the following:

The quinoline-based pincer nickel(II) complexes I (2a,b, X = Cl, R = Me, Et; 3a,b, X = Br, R = Me, Et; 4a, X = OAc, R = Me) were prepared by the reaction of the ligand precursors N-[(2-dialkylamino)phenyl]-8-quinolinamines with (DME)NiCl₂ (THF)₂NiBr₂ or Ni(OAc)₂ in the presence of Et₃N. All of these complexes were characterized by ¹H and ¹³C NMR spectroscopy as well as by elemental anal. Further, the mol. structures of 2a and 3a,b were elucidated by x-ray crystallog. Complex 2a is found to be an efficient catalyst for the direct C-H bond alkylation of substituted benzothiazoles and oxazoles in 2-position with various unactivated alkyl halides containing 閻?hydrogens under mild reaction conditions. The catalyst 2a is very robust and was recycled and reused five times for the alkylation reaction without a decrease in its catalytic activity. Preliminary studies reveal that the catalyst 2a acts as an active catalyst and the alkylation reaction appears to operate via a radical pathway. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-activity relationships of N²-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases was written by Hildebrand, Catherine;Sandoli, Daniele;Focher, Federico;Gambino, Joseph;Ciarrocchi, Giovanni;Spadari, Silvio;Wright, George. And the article was included in Journal of Medicinal Chemistry in 1990.Recommanded Product: 3,4-Dibromoaniline This article mentions the following:

Guanines I [R = Ph, substituted Ph, Bu, hexyl, (CH₂)₅OH, CH₂Ph, CH₂C₆H₄Cl] were prepared and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2. Compounds with hydrophobic, electron-attracting groups in the meta position of the Ph ring such as I (R = 3-CF₃C₆H₄) were the most potent inhibitors of both enzymes. Many derivatives were significantly more potent against the type 2 thymidine kinase than against the type 1 and can effectively discriminate between the two enzymes. I [R = alkyl, (un)substituted CH₂Ph] were moderately potent inhibitors, and the type 2 enzyme was again more sensitive than the type 1 enzyme. None of the compounds inhibited the thymidine kinase isolated from the host HeLa cell line, suggesting that members of this class of compounds may be useful nonsubstrate, antiviral compounds for latent herpesvirus infections. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electroreductive Nickel-Catalyzed Thiolation: Efficient Cross-Electrophile Coupling For C-S Formation was written by Ang, Nate W. J.;Ackermann, Lutz. And the article was included in Chemistry – A European Journal in 2021.Reference of 14425-64-0 This article mentions the following:

An efficient and mild electrochem. thiolation by cross-electrophile coupling of alkyl bromides with functionalized bench-stable thiosulfonates to access alkyl sulfides RSR¹ [R = (CH₂)₅Cl, Cy, (CH₂)₂Ph, etc.; R¹ = Cy, Ph, 2-thienyl, etc.] with excellent efficacy and broad functional group tolerance. Cyclic voltammetry and potentiostatic anal. were performed to elucidate mechanistic insights into this electrocatalytic thiolation reaction. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Reference of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bifunctional Indenyl-Derived Receptors for Fluoride Chelation and Detection was written by Tirfoin, Remi;Abdalla, Joseph A. B.;Aldridge, Simon. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 3,4-Dibromoaniline This article mentions the following:

Anion receptors based on a [CpFe(indenyl)] scaffold offer the possibility for the incorporation of adjacent Lewis acidic functions onto a six-membered carbocyclic framework, while at the same time retaining the colorimetric/electrochem. reporter mechanisms available to synthetically simpler ferrocene systems. Thus, [CpFe(indenyl)] systems featuring mutually ortho BMes₂ and PPh₂Me⁺ substituents (with either 4,5 or 5,6 regiochem.) are accessible which are capable of cooperative fluoride ion fixation. Simultaneous binding at the borane and phosphonium centers can be established by spectroscopic, structural and computational approaches, and is responsible for the favorable thermodn. associated with F^– uptake. Thus, in contrast to simple BMes₂ systems, the binding of fluoride is found to be more favorable than the uptake of cyanide (which interacts only with the borane Lewis acid). Moreover, in the case of a 4-(MePh₂P)-5-(Mes₂B)-7-Me-indenyl derivative, fluoride chelation is signalled not only by a large cathodic shift in the Fe^II/Fe^III potential (>500 mV in THF), but also by a distinct color change from green (for the free receptor) to maroon for the adduct. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application In Synthesis of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes was written by Maynard, John R. J.;Gallagher, Peter;Lozano, David;Butler, Patrick;Goldup, Stephen M.. And the article was included in Nature Chemistry in 2022.Computed Properties of C8H7BrO3 This article mentions the following:

The symmetry properties of these mols. and in doing so identify a straightforward route to access them from simple chiral building blocks was re-examined This anal. also led us to identify an analogous but previously unremarked upon rotaxane stereogenic unit, which also yielded to our co-conformational auxiliary approach. With methods to access mech. axially chiral mols. in hand, their properties and applications can now be explored. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Computed Properties of C8H7BrO3).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H7BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary