Month: February 2023

Design, Synthesis, and Fungicidal Evaluation of Novel Pyrazole-furan and Pyrazole-pyrrole Carboxamide as Succinate Dehydrogenase Inhibitors was written by Yao, Ting-Ting;Xiao, Dou-Xin;Li, Zhong-Shan;Cheng, Jing-Li;Fang, Shao-Wei;Du, Yong-Jun;Zhao, Jin-Hao;Dong, Xiao-Wu;Zhu, Guo-Nian. And the article was included in Journal of Agricultural and Food Chemistry in 2017.Synthetic Route of C7H8BrNO2 This article mentions the following:

The identification of novel succinate dehydrogenase (SDH) inhibitors represents one of the most attractive directions in the field of fungicide research and development. During our continuous efforts to pursue inhibitors belonging to this class, some structurally novel pyrazole-furan carboxamide and pyrazole-pyrrole carboxamide derivatives have been discovered via the introduction of scaffold hopping and bioisosterism to compound (I), a remarkably potent lead obtained by pharmacophore-based virtual screening. As a result of the evaluation against three destructive fungi, including Sclerotinia sclerotiorum, Rhizoctonia solani, and Pyricularia grisea, a majority of them displayed potent fungicidal activities. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3Synthetic Route of C7H8BrNO2).

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C7H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-catalyzed annulation of 2-bromobenzoic esters with terminal alkynes towards 3-substituted isocoumarins was written by Sun, Mengli;Su, Lebin;Dong, Jianyu;Liu, Long;Zhou, Yongbo;Yin, Shuang-Feng. And the article was included in Tetrahedron Letters in 2017.Recommanded Product: Methyl 2-bromo-4-fluorobenzoate This article mentions the following:

An efficient method for the synthesis of 3-substituted isocoumarins that are an important class of biol. active scaffolds via annulation of 2-bromobenzoic esters with terminal alkynes using copper catalyst was described. The advantages of this method included mild reaction conditions, high yield and regioselectivity, and wide tolerance toward functional groups. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Recommanded Product: Methyl 2-bromo-4-fluorobenzoate).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: Methyl 2-bromo-4-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Influence of Polymer Backbone Fluorination on the Electrochemical Behavior of Single-Ion Conducting Multiblock Copolymer Electrolytes was written by Mayer, Alexander;Nguyen, Huu-Dat;Mariani, Alessandro;Diemant, Thomas;Lyonnard, Sandrine;Iojoiu, Cristina;Passerini, Stefano;Bresser, Dominic. And the article was included in ACS Macro Letters in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

The presence of fluorine, especially in the electrolyte, frequently has a beneficial effect on the performance of lithium batteries owing to, for instance, the stabilization of the interfaces and interphases with the pos. and neg. electrodes. However, the presence of fluorine is also associated with reduced recyclability and low biodegradability. Herein, we present a single-ion conducting multiblock copolymer electrolyte comprising a fluorine-free backbone and compare it with the fluorinated analog reported earlier. Following a comprehensive physicochem. and electrochem. characterization of the copolymer with the fluorine-free backbone, the focus of the comparison with the fluorinated analog was particularly on the electrochem. stability toward oxidation and reduction as well as the reactions occurring at the interface with the lithium-metal electrode. To deconvolute the impact of the fluorine in the ionic side chain and the copolymer backbone, suitable model compounds were identified and studied exptl. and theor. The results show that the absence of fluorine in the backbone has little impact on the basic electrochem. properties, such as the ionic conductivity, but severely affects the electrochem. stability and interfacial stability. The results highlight the need for a very careful design of the whole polymer for each desired application, essentially, just like for liquid electrolytes. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes was written by Dumas, Megan E.;Chen, Geng-Yuan;Kendrick, Nicole D.;Xu, George;Larsen, Scott A.;Jana, Somnath;Waterson, Alex G.;Bauer, Joshua A.;Hancock, William;Sulikowski, Gary A.;Ohi, Ryoma. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Product Details of 108940-96-1 This article mentions the following:

The mitotic spindle is a microtubule-based machine that segregates a replicated set of chromosomes during cell division. Many cancer drugs alter or disrupt the microtubules that form the mitotic spindle. Microtubule-dependent mol. motors that function during mitosis are logical alternative mitotic targets for drug development. Eg5 (Kinesin-5) and Kif15 (Kinesin-12), in particular, are an attractive pair of motor proteins, as they work in concert to drive centrosome separation and promote spindle bipolarity. Furthermore, we hypothesize that the clin. failure of Eg5 inhibitors may be (in part) due to compensation by Kif15. In order to test this idea, we screened a small library of kinase inhibitors and identified GW108X, an oxindole that inhibits Kif15 in vitro. We show that GW108X has a distinct mechanism of action compared with a com. available Kif15 inhibitor, Kif15-IN-1 and may serve as a lead with which to further develop Kif15 inhibitors as clin. relevant agents. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Product Details of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Product Details of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and structure activity relationship of 1,3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors was written by Wolff, Benjamin;Jaensch, Niklas;Sugiarto, Wisely Oki;Fruehschulz, Stefan;Lang, Maraike;Altintas, Rabia;Oehme, Ina;Meyer-Almes, Franz-Josef. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 85118-24-7 This article mentions the following:

Here, the synthesis of 2,3-dihydroimidazo[1,2-c][1,3]benzothiazine-5-thiones I [R¹ = H, Me, Br, etc.; R² = H, Br, I, etc.; R³ = H, Me, Cl, etc.; R⁴ = H, Me, Cl, F; n = 0] and 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazine-6-thiones I [n = 1] was described that demonstrated great selectivity for HDAC8 and chem. stability in the presence of GSH. The compounds were characterized with respect to structure-activity relationship, binding mode and target engagement in neuroblastoma cells by combining biochem. and biophys. methods with chemoinformatics. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Recommanded Product: 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen was written by Dai, Chaofeng;Cazares, Lisa H.;Wang, Lifang;Chu, Yong;Wang, Siming L.;Troyer, Dean A.;Semmes, O. John;Drake, Richard R.;Wang, Binghe. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Synthetic Route of C12H16BBrO2 This article mentions the following:

Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, the authors have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Synthetic Route of C12H16BBrO2).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C12H16BBrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrohalogenation of ethyl halides was written by Ahubelem, Nwakamma;Altarawneh, Mohammednoor;Dlugogorski, Bogdan Z.. And the article was included in Tetrahedron Letters in 2014.Synthetic Route of C9H11BrO This article mentions the following:

Unimol. decomposition kinetics of selected Et halides, phenethyl halides and methoxyphenethyl halides were studied using high level computational chem. methods. The phenethyl halides decompose faster than the Et halides due to a more electroneg. chlorine atom, induced by the chloroethyl functionality as an electron-withdrawing group. 1-Chloro-2-(methylthio)ethane exhibits faster dehydrochlorination than that of chloroethane/1-chloro-2-methoxyethane, owing to more polarizable C···H and C···Cl bonds in the transition structures. Calculations suggest that electronic factors rather than anchimeric assistance influence the dehydrochlorination reactions. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Synthetic Route of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ni-catalyzed migratory fluoro-alkenylation of unactivated alkyl bromides with gem-difluoroalkenes was written by Zhou, Lu;Zhu, Chuan;Bi, Peijia;Feng, Chao. And the article was included in Chemical Science in 2019.Application of 14425-64-0 This article mentions the following:

Nickel-catalyzed highly regio- and stereoselective migratory fluoro-alkenylation of unactivated alkyl bromides was reported. Catalytic cycle merged alkyl nickel chain-walking and defluorinative coupling enabled the introduction of a broad array of fluoroalkenyl moieties into carbon chains. Control experiments with other halogenated alkenes demonstrated the essential role of fluorine atoms in this reaction. The reaction proceeded under mild conditions and allowed for the synthesis of a variety of valuable monofluoroalkenes. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Improved preparation of hexakis(6-deoxy)cyclomaltohexaose and heptakis(6-deoxy)cyclomaltoheptaose was written by Baer, Hans H.;Vargas Berenguel, Antonio;Shu, Youn Y.;Defaye, Jacques;Gadelle, Andree;Santoyo Gonzalez, Francisco. And the article was included in Carbohydrate Research in 1992.HPLC of Formula: 53784-83-1 This article mentions the following:

Title compounds I (R = H; n = 6, 7) were prepared from I (R = OH) by direct halogenation with Br or iodine and DMF-PPh₃, followed by reductive dehalogenation with NaBH₄. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1HPLC of Formula: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Infrared studies of 3-fluoro-6-bromotoluene and 4-fluoro-3-bromotoluene was written by Singh, I. D.;Sarowha, S. L. S.. And the article was included in Acta Ciencia Indica, Physics in 1980.Application of 452-62-0 This article mentions the following:

The IR absorption spectra of 3-fluoro-6-bromotoluene and 4-fluoro-3-bromotoluene in the form of thin films were investigated in the frequency range 200-4000 cm^-1. Modes of vibrations were assigned to different observed vibrational frequencies in each case. Me group vibrations are discussed. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Application of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary