Month: February 2023

Mechanistic change in the reactivity of substituted phenyl acetates over phenyl thiolacetates toward imidazole in aqueous phase was written by Rajarathnam, D.;Jeyakumar, T.;Nadar, P. Ananthakrishna. And the article was included in International Journal of Chemical Kinetics in 2005.SDS of cas: 35065-86-2 This article mentions the following:

The kinetics of aminolysis of several substituted Ph acetates by imidazole is studied in aqueous medium at 20°C and an ionic strength of 0.1 M (KCl). By following the leaving groups spectrophotometrically (λ_max = 272-401 nm), under excess free imidazole, pseudo-first-order rate constants (k_obs) are obtained. For the esters with good nucleofuges, the reaction follows clean second-order kinetics and the plots of (k_obs – k_H) against free imidazole concentration are linear at constant pH. The macroscopic nucleophilic substitution rate constants (k_N) are obtained as the slopes of these plots and are pH independent. For the esters with poor nucleofuges, a rate dependence on more than first power of the free imidazole and a linear dependence of k’₂ on free imidazole is observed Accordingly, the microscopic rate constants for the assisted paths viz. k_ga and k_gb were disseminated besides for simple bimol. attack. The Broensted-type plots and Hammett plots were constructed whose slope values are consistent with a stepwise mechanism through a bipolar tetrahedral addition intermediate whose formation or breakdown being rate determining for various paths. Comparison of this reaction of oxyesters with the earlier reported works on similar reaction of analog thiolesters under identical reaction conditions showed remarkable mechanistic differences which are discussed. The discussion is extended to include the details on previously studied ammonolysis of these two types of esters wherein thiolesters showed differed reactivity than that reported. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2SDS of cas: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Asymmetric synthesis of functionalized tetrahydrofluorenones via an NHC-catalyzed homoenolate Michael addition was written by Shu, Tao;Li, Sun;Chen, Xiang-Yu;Liu, Qiang;von Essen, Carolina;Rissanen, Kari;Enders, Dieter. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C8H4BrF3O This article mentions the following:

The first example of an N-heterocyclic carbene-catalyzed asym. desymmetrization of enal-tethered cyclohexadienones via an intramol. homoenolate Michael addition/esterification reaction was described. This new protocol offered a direct entry to various functionalized tetrahydrofluorenones with three contiguous stereocenters in high yields, good diastereoselectivities and excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Computed Properties of C8H4BrF3O).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C8H4BrF3O

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective halogenation of cyclic maltose oligosaccharides in the C-6 position and synthesis of per(3,6-anhydro) cyclic maltose oligosaccharides was written by Gadelle, Andree;Defaye, Jaques. And the article was included in Angewandte Chemie in 1991.Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

Cyclic maltose oligosaccharides were treated with PPh₃ and iodine (or bromine) to give the per-6-deoxy-6-halo derivatives Treatment of per(6-deoxy-6-iodo) cyclic maltose oligosaccharide with aqueous NaOH gave the per(3,6-anhydro) derivatives In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Light-mediated deoxygenation of alcohols with a dimeric gold catalyst was written by McCallum, Terry;Slavko, Ekaterina;Morin, Mathieu;Barriault, Louis. And the article was included in European Journal of Organic Chemistry in 2015.Related Products of 14425-64-0 This article mentions the following:

A new light-mediated protocol for the reductive deoxygenation of primary alcs. using dimeric gold ([Au₂(dppm)₂]Cl₂) as photoredox catalyst was reported. Moreover, the use of UVA light-emitting diodes significantly reduced reaction times and also lowered the setup cost. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Related Products of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A convenient one-pot access to phenanthridinones via Suzuki-Miyaura cross-coupling reaction was written by Tanimoto, Kouichi;Nakagawa, Naomichi;Takeda, Kazutaka;Kirihata, Mitsunori;Tanimori, Shinji. And the article was included in Tetrahedron Letters in 2013.Synthetic Route of C8H6BrFO2 This article mentions the following:

A convenient one-step access to biol. important phenanthridinones has been realized based upon Suzuki-Miyaura cross-coupling reaction. Reactions of 2-aminophenylboronic acid with 2-halobenzoate took place smoothly to afford substituted phenanthridinones in excellent yields in the presence of palladium(II) acetate and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) as pre-catalysts. A natural product phenaglydon was synthesized in one-pot manner from readily available starting materials in 95% yield. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Synthetic Route of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Self-Healing Heterometallic Supramolecular Polymers Constructed by Hierarchical Assembly of Triply Orthogonal Interactions with Tunable Photophysical Properties was written by Zhang, Qian;Tang, Danting;Zhang, Jinjin;Ni, Ruidong;Xu, Luonan;He, Tian;Lin, Xiongjie;Li, Xiaopeng;Qiu, Huayu;Yin, Shouchun;Stang, Peter J.. And the article was included in Journal of the American Chemical Society in 2019.Application of 108940-96-1 This article mentions the following:

Here, the authors present a method for the building of new bicyclic heterometallic cross-linked supramol. polymers by hierarchical unification of three types of orthogonal noncovalent interactions, including Pt(II)-pyridine coordination-driven self-assembly, Zn-terpyridine complex, and host-guest interactions. The Pt-pyridine coordination provides the primary driving force to form discrete rhomboidal metallacycles. The assembly does not interfere with the Zn-terpyridine complexes, which link the discrete metallacycles into linear supramol. polymers, and the conjugation length is extended upon the formation of the Zn-terpyridine complexes, which red shifts the absorption and emission spectra. Finally, host-guest interactions via bis-ammonium salt binding to the benzo-21-crown-7 (B21C7) groups on the Pt acceptors afford the cross-linked supramol. polymers. By continuous increase of the concentration of the supramol. polymer to a relatively high level, supramol. polymer gel was obtained, which exhibits self-healing properties and reversible gel-sol transitions stimulated by various external stimuli, including temperature, K⁺, and cyclen. Also, the photophys. properties of the supramol. polymers could be effectively tuned by varying the substituents of the precursor ligands. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Application of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of two photolabile benzyl manganese derivatives incorporating a geometrically inaccessible radical trap was written by Keana, John F. W.;Pou, Sovitj. And the article was included in Organic Preparations and Procedures International in 1989.Quality Control of 3-(Bromomethyl)benzoic acid This article mentions the following:

Synthesis of 2 title compounds I and II are described. Oxidation of 3,5-(BrCH₂)₂C₆H₃CO₂Me with (Bu₄N)₂Cr₂O₇ in CHCl₃ gave 31% monoformylated derivative which on 2 stepwise condensations with Me₃CNHOH and NaMn(CO)₅ gave I. Chlorination of 3-BrCH₂C₆H₄CO₂H with SOCl₂ followed by 2 stepwise condensations with 2,2,6,6-tetramethyl-4-amino-1-piperidinyloxy and MeMn(CO)₅ gave II. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Quality Control of 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles was written by Shailaja, M.;Anitha, M.;Manjula, A.;Rao, B. Vittal. And the article was included in Indian Journal of Chemistry in 2010.Electric Literature of C8H6BrFO2 This article mentions the following:

A new mol. framework of 1,3,4-oxadiazoles incorporating halopyridines was synthesized. The derivatives were synthesized starting from (pyridinyloxy)benzaldehydes, by conversion into the corresponding aroyl hydrazides followed by oxidative cyclization to the title compounds using chloramine-T. The 2,5-disubstituted 1,3,4-oxadiazoles were tested for antimicrobial activity. Many compounds showed a high degree of activity against Staphylococcus aureus and Escherichia coli at 250 μg/mL. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Electric Literature of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

New oxo-bridged dinuclear peroxotungsten(VI) complexes: Synthesis, stability and activity in bromoperoxidation was written by Hazarika, Pankaj;Kalita, Diganta;Sarmah, Swapnalee;Borah, Ruli;Islam, Nashreen S.. And the article was included in Polyhedron in 2006.Recommanded Product: 74440-80-5 This article mentions the following:

Two new dinuclear oxo-bridged peroxo complexes of tungsten with coordinated dipeptides of the type Na₂[W₂O₃(O₂)₄(glycyl-glycine)₂]•3H₂O (1) and Na₂[W₂O₃(O₂)₄(glycyl-leucine)₂]•3H₂O (2) have been synthesized from the reaction of H₂WO₄, 30% H₂O₂ and the resp. dipeptide at pH ca. 2.5. Synthesis of the complexes is sensitive to pH, reaction temperature and concentrations of the components. The complexes were characterized by elemental anal., spectral and physico-chem. methods including thermal anal. In the dimeric complexes the two W(VI) centers with edge bound peroxo groups are bridged by an oxo group. The dipeptides occurring as zwitterions bind the metal centers through carboxylate oxygen atoms leading to hepta coordination around each W(VI). Thermal stability of the compounds as well as their stability in solution were determined The complexes are highly stable toward decomposition in solutions of acidic as well as physiol. pH. Complexes 1, 2 and Na₂[W₂O₃(O₂)₄(cystine)]•4H₂O (3) catalyze the bromoperoxidn. of organic substrates at neutral pH in the presence of H₂O₂. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Recommanded Product: 74440-80-5).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 74440-80-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pd/C-Catalyzed Hydrogenolysis of Dibenzodioxocin Lignin Model Compounds Using Silanes and Water as Hydrogen Source was written by Subbotina, Elena;Galkin, Maxim V.;Samec, Joseph S. M.. And the article was included in ACS Sustainable Chemistry & Engineering in 2017.Application of 14425-64-0 This article mentions the following:

A mild Pd/C-catalyzed hydrogenolysis of the C-O bond of model compounds representing the dibenzodioxocin motif in lignin using polymethylhydrosiloxane (PMHS) and water as hydrogen sources was developed. The efficiency of the reaction is highly dependent on both water concentration and the addition of a base. The results from mechanistic studies showed that the benzylic C-O bond is cleaved faster than the terminal C-O bond, which only cleaves upon the presence of the neighboring phenol. We propose a hydrogen bond formation between an oxygen atom of an ether group and a proton of a neighboring phenol under the employed mild reaction conditions, which facilitates cleavage of the C-O bond. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary