On February 15, 2021, Yang, Ling; Tan, Dong-Hang; Fan, Wen-Xin; Liu, Xu-Ge; Wu, Jia-Qiang; Huang, Zhi-Shu; Li, Qingjiang; Wang, Honggen published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Photochemical Radical C-H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates. And the article contained the following:
Benzylboronates ArCH2B(MIDA) were halogenated in α-position by reaction with NBS either initiated with benzyl peroxide or photochem., giving α-haloboronates ArCHXB(MIDA). Fluorination and chlorination were performed by reactions with Selectfluor and NCS, resp., under 9-fluorenone catalysis. α-Haloboronates are useful organic synthons that can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochem. radical C-H halogenation of benzyl N-methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination, and bromination reactions were effective by using this protocol. Upon reaction with different nucleophiles, the C-Br bond in the brominated product could be readily transformed to a series of C-C, C-O, C-N, C-S, C-P, and C-I bonds, some of which are difficult to forge with α-halo sp2-B boronate esters. An activation effect of B(MIDA) moiety was found. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl
The Article related to bmida methyliminodiacetyl boronate photochem halogenation preparation haloboronate, halogenation, ketone catalysis, organoboron, photochemistry, radical reaction, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary