On January 31, 2020, Zhang, Xinwei; Zhang, Cunlong; Tang, Lin; Lu, Kuan; Zhao, Huan; Wu, Weibin; Jiang, Yuyang published an article.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Synthesis and biological evaluation of piperidyl benzimidazole carboxamide derivatives as potent PARP-1 inhibitors and antitumor agents. And the article contained the following:
A series of compounds based on a piperidyl benzimidazole carboxamide structure and tested their PARP-1 inhibitory activity, as well as cellular inhibitory activity. Some of them showed great potency as PARP-1 inhibitors and antitumor activity, which were valuable for further research. In addition, the predicted ADME properties and proposed binding mode with PARP-1 of the compounds were obtained via computational simulation. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to alkyl amidobenzimidazolyl piperidine preparation parp inhibition antitumor sar pharmacokinetics, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 2-(2-Bromoethyl)isoindoline-1,3-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary