Sisto, Francesca; Carradori, Simone; Guglielmi, Paolo; Traversi, Carmen Beatrice; Spano, Mattia; Sobolev, Anatoly P.; Secci, Daniela; Di Marcantonio, Maria Carmela; Haloci, Entela; Grande, Rossella; Mincione, Gabriella published an article in 2020, the title of the article was Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. pylori strains and AGS cell proliferation.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:
This study reports on the synthesis, structural assessment, microbiol. screening against several strains of H. pylori and antiproliferative activity against human gastric adenocarcinoma (AGS) cells of a large series of carvacrol-based compounds Structural analyses consisted of elemental anal., 1H/13C/19F NMR spectra and crystallog. studies. The structure-activity relationships evidenced that among ether derivatives the substitution with specific electron-withdrawing groups (CF3 and NO2) especially in the para position of the benzyl ring led to an improvement of the antimicrobial activity, whereas electron-donating groups on the benzyl ring and ethereal alkyl chains were not tolerated with respect to the parent compound (MIC/MBC = 64/64 μg/mL). Ester derivatives (coumarin-carvacrol hybrids) displayed a slight enhancement of the inhibitory activity up to MIC values of 8-16 μg/mL. The most interesting compounds exhibiting the lowest MIC/MBC activity against H. pylori (among others, compounds 16 and 39 endowed with MIC/MBC values ranging between 2/2 to 32/32 μg/mL against all the evaluated strains) were also assayed for their ability to reduce AGS cell growth with respect to 5-Fluorouracil. Some derivatives can be regarded as new lead compounds able to reduce H. pylori growth and to counteract the proliferation of AGS cells, both contributing to the occurrence of gastric cancer. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl
The Article related to helicobacter gastric adenocarcinoma cell proliferation, ags cells, helicobacter pylori, carvacrol, coumarin, drug resistance, dual agent, semi-synthesis, Placeholder for records without volume info and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary