On March 31, 2020, Babin, Victor; Tournier, Benjamin B.; Davis, Audrey; Dubost, Emmanuelle; Pigree, Gilbert; Lohier, Jean-Francois; Reboul, Vincent; Cailly, Thomas; Bouillon, Jean-Philippe; Millet, Philippe; Fabis, Frederic published an article.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Design of iodinated radioligands for SPECT imaging of central human 5-HT4R using a ligand lipophilicity efficiency approach. And the article contained the following:
A series of iodinated ligands for the SPECT imaging of 5-HT4 receptors was designed starting from the previously reported hit MR-26132. We focused on the modulation of the piperidine-containing lateral chain by introducing hydrophilic groups in order to decrease the lipophilicity of the new ligands. All the synthesized compounds were tested for their binding affinities on 5-HT4Rs and based on the Ligand Lipophilicity Efficiency approach, compound 13 was further selected for radioiodination with iodine-125 and imaging experiments Compound 13 showed its ability to displace the specific signal of the reference compound [125I]SB-207710 but no significant detection of [125I]13 was observed in vivo in SPECT experiments The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to iodinated radioligand preparation spect imaging 5ht4 receptor lipophilicity, 5-ht(4), lle, radio-iodination, spect imaging, serotonin, Placeholder for records without volume info and other aspects.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary