On October 1, 2006, Beaulieu, Pierre L.; Gillard, James; Bykowski, Darren; Brochu, Christian; Dansereau, Nathalie; Duceppe, Jean-Simon; Hache, Bruno; Jakalian, Araz; Lagace, Lisette; LaPlante, Steven; McKercher, Ginette; Moreau, Elaine; Perreault, Stephane; Stammers, Timothy; Thauvette, Louise; Warrington, Jeff; Kukolj, George published an article.Category: bromides-buliding-blocks The title of the article was Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds. And the article contained the following:
Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topol. related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ∼ 50 nM). The experimental process involved the reaction of Methyl 5-bromo-2-methoxy-4-methylbenzoate(cas: 39503-58-7).Category: bromides-buliding-blocks
The Article related to indole derivative preparation antiviral hepatitis c virus polymerase inhibitor, Pharmacology: Structure-Activity and other aspects.Category: bromides-buliding-blocks
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