Ma, Yucheng; Zhuang, Zeyan; Xing, Longjiang; Li, Jianqing; Yang, Zhiwen; Ji, Shaomin; Hu, Rong; Zhao, Zujin; Huo, Yanping; Tang, Ben Zhong published an article in 2021. The article was titled 《The AIE-Active Dual-Cationic Molecular Engineering: Synergistic Effect of Dark Toxicity and Phototoxicity for Anticancer Therapy》, and you may find the article in Advanced Functional Materials.Product Details of 4316-58-9 The information in the text is summarized as follows:
The development of anticancer therapy is significant to human health but remains a huge challenge. Photodynamic therapy (PDT), inducing the synergistic mitochondrial dysfunction in cancer cells is a promising approach but suffer from the low efficiency in hypoxic microenvironment and deep-seated tumors. Herein, to improve the outcomes of PDT for cancer treatment, a series of red fluorophores consisting of dual-cationic triphenylphosphonium-alkylated pyridinium and (substituted) triphenylamine are prepared as organelle-targeting antitumor photosensitizers (PSs) with aggregation-induced emission characteristics. These PSs can selectively accumulate at the mitochondria or lysosomes of cancer cells with both dark- and photo-cytotoxicity, making them possess excellent killing effect on cancer cells and efficient inhibition of tumor growth in living mice. This study brings about new insight into the development of powerful cancer treatment. The results came from multiple reactions, including the reaction of Tris(4-bromophenyl)amine(cas: 4316-58-9Product Details of 4316-58-9)
In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Product Details of 4316-58-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary