《Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs》 was written by Carter, David S.; Jacobs, Robert T.; Freund, Yvonne R.; Berry, Pamela W.; Akama, Tsutomu; Easom, Eric E.; Lunde, Christopher S.; Rock, Fernando; Stefanakis, Rianna; McKerrow, James; Fischer, Chelsea; Bulman, Christina A.; Lim, Kee Chong; Suzuki, Brian M.; Tricoche, Nancy; Sakanari, Judy A.; Lustigman, Sara; Plattner, Jacob J.. Synthetic Route of C8H7BrO2 And the article was included in ACS Infectious Diseases in 2020. The article conveys some information:
The optimization of a series of benzimidazole-benzoxaborole hybrid mols. linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness, is described. The lead identified in this series, 21 (AN15470), was found to have acceptable pharmacokinetic properties to enable an evaluation following oral dosing in an animal model of onchocerciasis. Compound 21was effective in killing worms implanted in Mongolian gerbils when dosed orally as a suspension at 100 mg/kg/day for 14 days but not when dosed orally at 100 mg/kg/day for 7 days. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Synthetic Route of C8H7BrO2)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Synthetic Route of C8H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary