In 2019,Nature Communications included an article by Zhang, Wenjia; Hu, Xianglong; Shen, Qi; Xing, Da. Category: bromides-buliding-blocks. The article was titled 《Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy》. The information in the text is summarized as follows:
Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approx. 90% of intracellular ROS is produced in mitochondria. In situ mitochondrial ROS amplification is a promising strategy to enhance cancer therapy. Here we report cancer cell and mitochondria dual-targeting polyprodrug nanoreactors (DT-PNs) covalently tethered with a high content of repeating camptothecin (CPT) units, which release initial free CPT in the presence of endogenous mitochondrial ROS (mtROS). The in situ released CPT acts as a cellular respiration inhibitor, inducing mtROS upregulation, thus achieving subsequent self-circulation of CPT release and mtROS burst. This mtROS amplification endows long-term high oxidative stress to induce cancer cell apoptosis. This current strategy of endogenously activated mtROS amplification for enhanced chemodynamic therapy overcomes the short lifespan and action range of ROS, avoids the penetration limitation of exogenous light in photodynamic therapy, and is promising for theranostics. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Category: bromides-buliding-blocks)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary