《Reductive sp3-sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals》 was published in Organic Letters in 2020. These research results belong to Mennie, Katrina M.; Vara, Brandon A.; Levi, Samuel M.. HPLC of Formula: 3395-91-3 The article mentions the following:
Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp3 character of mols. enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp3-sp2 cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with a broad range of primary and secondary alkyl halide coupling partners. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3HPLC of Formula: 3395-91-3)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 3395-91-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary