《Masked phenolic-selenium conjugates: potent and selective antiproliferative agents overcoming P-gp resistance》 was written by Begines, Paloma; Sevilla-Horrillo, Lucia; Puerta, Adrian; Puckett, Rebecca; Bayort, Samuel; Lagunes, Irene; Maya, Ines; Padron, Jose M.; Lopez, Oscar; Fernandez-Bolanos, Jose G.. Reference of 4-Bromobutanoic acid And the article was included in Pharmaceuticals in 2020. The article conveys some information:
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached. In recent years, multitarget drugs are gaining great attention against multifactorial diseases in contraposition to polypharmacy. Herein we have accomplished the conjugation of phenolic derivatives with an ample number of organochalcogen motifs with the aim of developing novel antiproliferative agents. Their antioxidant, and antiproliferative properties (against six tumor and one non-tumor cell lines) were analyzed. Moreover, in order to predict P-gp-mediated chemoresistance, the P-glycoprotein assay was also conducted in order to determine whether compounds prepared herein could behave as substrates of that glycoprotein. Selenium derivatives were found to be significantly stronger antiproliferative agents than their sulfur isosters. Moreover, the length and the nature of the tether, together with the nature of the organoselenium scaffold were also found to be crucial features in the observed bioactivities. The lead compound, bearing a methylenedioxyphenyl moiety, and a diselenide functionality, showed a good activity (GI50 = 0.88-2.0μM) and selectivity towards tumor cell lines (selectivity index: 14-32); moreover, compounds considered herein were not substrates for the P-gp efflux pump, thus avoiding the development of chemoresistance coming from such mechanism, commonly found for widely-used chemotherapeutic agents. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary