In 2022,Zhao, He; Wu, Yang; Ci, Chenggang; Tan, Zhenda; Yang, Jian; Jiang, Huanfeng; Dixneuf, Pierre H.; Zhang, Min published an article in Nature Communications. The title of the article was 《Intermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis》.HPLC of Formula: 5437-45-6 The author mentioned the following in the article:
Derivatization of azaarenes can create mols. of biol. importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in the azaarenes, and that paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemoselectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6HPLC of Formula: 5437-45-6)
Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.HPLC of Formula: 5437-45-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary