《Photoredox-Catalyzed Stereoselective Synthesis of C-Nucleoside Analogs from Glycosyl Bromides and Hetero-arenes》 was written by Xia, Liwen; Fan, Wenjing; Yuan, Xiang-Ai; Yu, Shouyun. HPLC of Formula: 21085-72-3 And the article was included in ACS Catalysis in 2021. The article conveys some information:
C-nucleosides, analogs of nucleosides by replacing a C-N glycosidic bond with a C-C bond, are potential anticancer or antiviral agents. Synthesis of C-nucleoside analogs, e.g. I, enabled by photoredox-catalyzed radical coupling of glycosyl bromides with non-functionalized hetero-arenes has been described. This strategy features readily available starting materials, mild conditions, good functional group tolerance, and site- and stereoselectivities (α-configuration). A variety of monosaccharides (D-lyxose, D-ribose, L-arabinose, D-glucose, D-mannose, D-glucuronide, and D-fucose), disaccharides (lactose, melibiose, and maltose), and polysaccharide can couple with a series of non-functionalized hetero-arenes, such as purine, benzothiazole, thiazolo-pyridine, benzoxazole, benzimidazole, imidazopyridine, and phenanthridine. Biol. important mols., such as theophylline, famciclovir, ribofuranoside, and adenine, can be glycosylated directly through a C-C bond using this method. Site- and stereoselectivities can be rationalized and predicted by DFT calculations In the experimental materials used by the author, we found (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3HPLC of Formula: 21085-72-3)
(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.HPLC of Formula: 21085-72-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary