In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16518-62-0, name is 3-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-Bromo-N,N-dimethylaniline
TO A MIXTURE OF] [PALLADIUM (II)] acetate (3 mg, 5 [MOLpercent),] [2-DICYCLOHEXYLPHOSPHINO-2APOS;- (N,] N- dimethylamino) biphenyl (10 mg, 5 molpercent) and lithium bis (trimethylsilyl) amide (0.55 mL, 0.55 mmol, 1.1 equiv, 1.0 M solution in tetrahydrofuran) in toluene (0.5 mL) under nitrogen at-10 [¡ãC,] was added a solution of [3- [5- (3, 4-DICHLORO-] [PHENYL)-1-(2, 4-DICHLORO-PHENYL)-1H-PYRAZOL-3-YL]-PROPIONIC] acid tert-butyl ester (243 mg, 0.50 mmol, 1.0 equiv) in toluene (1.0 mL). This mixture was stirred at [- 10 ¡ãC] for 10 min, then (3-bromo-phenyl)-dimethyl-amine (42 mg, 0.21 mmol, 0.45 equiv) in toluene (0.5 mL) was added. The resulting solution was allowed to warm to room temperature then was heated to 80 [¡ãC] for 3 h. The reaction mixture was cooled to room temperature, and the reaction was quenched with satd aq ammonium chloride (1.0 mL). Water (10.0 mL) was added, and the resulting mixture was extracted with diethyl ether (2 x 10 mL). The combined extracts were washed with brine (10 mL), dried [(NA2SO4),] and concentrated under reduced pressure. The crude material was purified by reversed-phase HPLC to afford the desired aryl acetic acid ester (20 mg, 16percent). MS [(ESI)] : mass [CALCULATED FOR C30H29CI4N302,] 603.10 ; [M/Z] found, 604.1 [M+H] [+.]
The synthetic route of 16518-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2004/7463; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary