In 2022,Liu, Jianming; Wang, Xiaopei; Wang, Zhiyue; Yang, Yan; Tang, Qinghu; Liu, Hongchi; Huang, Hanmin published an article in iScience. The title of the article was 《Unlocking a self-catalytic cycle in a copper-catalyzed aerobic oxidative coupling/cyclization reaction》.Category: bromides-buliding-blocks The author mentioned the following in the article:
A copper-catalyzed, aerobic oxidative C-H/C-H cyclization reaction, occurs by cleaving the C-H and N-H bonds of 3-phenylindoles, e.g., I. A broad range of 3-phenylindoles I can be well tolerated to produce the indole-containing polycyclic aromatic hydrocarbons (PAH), e.g., II in good to excellent yields. An evaluation of the reaction mechanism is enabled by the isolation of the di-, e.g., III and tri-indole intermediates, e.g., IV highlighting the role of the substrate for this catalytic reaction. The results of these controlled experiments and kinetic studies provide solid exptl. support for a self-catalysis reaction, which has rarely been observed in oxidative C-H activation reactions. Addnl. mechanistic studies indicate that the substrate for this reaction accelerates by the following mechanism: the substrate combines with the Cu catalyst to transform the less active di-indole intermediate into a tri-indole intermediate. This intermediate is quickly converted into the desired product along with regeneration of the substrate copper complex. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Category: bromides-buliding-blocks)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Category: bromides-buliding-blocks1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary