Chen, Weixiong published the artcileDiscovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold, Formula: C8H7BrO3, the main research area is benzoisothiazolone scaffold SARSCoV2 coronavirus Mpro inhibitor COVID19; Benzoisothiazolone; COVID-19; Main protease inhibitors; SARS-CoV-2.
The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small mol. compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.
Bioorganic & Medicinal Chemistry Letters published new progress about Anticoronaviral agents. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Formula: C8H7BrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary