Wang, Yi-Ting published the artcileNovel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2, COA of Formula: C8H7BrO3, the main research area is nucleocapsid protein phenanthridine inhibitor SARS CoV2 coronavirus COVID19; N-terminal domain; Nucleocapsid protein; Phenanthridine; SARS-CoV-2.
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unprecedented in human history. As a major structural protein, nucleocapsid protein (NPro) is critical to the replication of SARS-CoV-2. In this work, 17 NPro-targeting phenanthridine derivatives were rationally designed and synthesized, based on the crystal structure of NPro. Most of these compounds can interact with SARS-CoV-2 NPro tightly and inhibit the replication of SARS-CoV-2 in vitro. Compounds 12 and 16 exhibited the most potent anti-viral activities with 50% effective concentration values of 3.69 and 2.18μM, resp. Furthermore, site-directed mutagenesis of NPro and Surface Plasmon Resonance (SPR) assays revealed that 12 and 16 target N-terminal domain (NTD) of NPro by binding to Tyr109. This work found two potent anti-SARS-CoV-2 bioactive compounds and also indicated that SARS-CoV-2 NPro-NTD can be a target for new anti-virus agents.
European Journal of Medicinal Chemistry published new progress about Anticoronaviral agents. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, COA of Formula: C8H7BrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary