Moreno-Sanz, Guillermo published the artcileSynthesis and Structure-Activity Relationship Studies of O-Biphenyl-3-yl Carbamates as Peripherally Restricted Fatty Acid Amide Hydrolase Inhibitors, COA of Formula: C8H7BrO3, the main research area is biphenyl carbamate preparation peripherally restricted FAAH inhibitor SAR; URB937 analog brain impermeant fatty acid amide hydrolase inhibitor; restricted access central nervous system biphenyl carbamate derivative.
The peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor URB937 (I, cyclohexylcarbamic acid 3′-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from the brain and spinal cord by the Abcg2 efflux transporter. Despite its inability to enter the central nervous system (CNS), I exerts profound antinociceptive effects in mice and rats, which result from the inhibition of FAAH in peripheral tissues and the consequent enhancement of anandamide signaling at CB1 cannabinoid receptors localized on sensory nerve endings. In the present study, we examined the structure-activity relationships (SAR) for the biphenyl region of compound I, focusing on the carbamoyl and hydroxyl groups in the distal and proximal Ph rings. Our SAR studies generated a new series of peripherally restricted FAAH inhibitors and identified compound II (cyclohexylcarbamic acid 3′-carbamoyl-5-hydroxybiphenyl-3-yl ester) as the most potent brain-impermeant FAAH inhibitor disclosed to date.
Journal of Medicinal Chemistry published new progress about Blood-brain barrier. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, COA of Formula: C8H7BrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary