Cacheux, Fanny published the artcileThe Piancatelli rearrangement of non-symmetrical furan-2,5-dicarbinols for the synthesis of highly functionalized cyclopentenones, Computed Properties of 452-63-1, the main research area is hydroxymethyl hydroxycyclopentenone preparation regioselective diastereoselective antitumor activity microwave irradiation; furan dicarbinol preparation Piancatelli rearrangement dysprosium chloride catalyst; aminocyclopentenone preparation regioselective diastereoselective microwave irradiation; aniline furan dicarbinol Aza Piancatelli rearrangement.
Substituted and non-sym. furan-2,5-dicarbinols I (R = Ph, 4-fluoro-2-methylphenyl, phenanthren-9-yl, 1,3-benzodioxol-5-yl, etc.) were readily prepared from 5-(hydroxymethyl)furfural (HMF), a renewable raw material from biomass. The Piancatelli rearrangement of these furan-2,5-dicarbinols I, catalyzed by DyCl3and under microwave activation, affords 5-substituted-4-hydroxymethyl-4-hydroxycyclopentenones (4S,5R)/(4S,5S)-II in a regio- and diastereoselective manner. This methodol. can be extended to aza-Piancatelli type reactions by using nitrogen nucleophiles, to furnish the corresponding aminocyclopentenone derivatives III (R1 = I, Br). Some of these synthesized bis-hydroxylated cyclopentenone derivatives exhibited significant cytotoxicity against eight human tumor cell lines.
Organic Chemistry Frontiers published new progress about Antitumor agents. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Computed Properties of 452-63-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary