Wang, Fan published the artcileAn Improved and Economical Process for the Manufacture of the Key Intermediate of Aliskiren, a New Potent Renin Inhibitor, Computed Properties of 172900-69-5, the main research area is aliskiren intermediate preparation; aminomethoxymethoxypropoxybenzylmethylhexanoic acid preparation; lhexanoic acid aminomethoxymethoxypropoxybenzylmethyl preparation.
An improved, practical, economical and efficient process for the production of (2S,4S)-2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoic acid, a key intermediate of the new potent renin inhibitor of aliskiren, in a total yield over 30% is described. This process avoids expensive reagents and chromatog. purifications, and is easily scaled up in industry.
Organic Process Research & Development published new progress about aliskiren intermediate preparation; aminomethoxymethoxypropoxybenzylmethylhexanoic acid preparation; lhexanoic acid aminomethoxymethoxypropoxybenzylmethyl preparation. 172900-69-5 belongs to class bromides-buliding-blocks, name is 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene, and the molecular formula is C17H27BrO3, Computed Properties of 172900-69-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary