Hodges, Alastair J. published the artcileIntramolecular nitrone dipolar cycloadditions: control of regioselectivity and synthesis of naturally-occurring spirocyclic alkaloids, HPLC of Formula: 69361-41-7, the publication is Organic & Biomolecular Chemistry (2012), 10(45), 8963-8974, database is CAplus and MEDLINE.
The intramol. nitrone dipolar cycloaddition of in situ-generated nitrones such as compound I has been used for the synthesis of cyclic isoxazolidines II and III. The regioselectivity of the intramol. cycloaddition depends on the nature of the terminal substituent on the dipolarophile. The influence of the substituent on the regioselectivity of the cycloaddition has been examined using several model systems and two methods of nitrone formation. These studies demonstrated that the cyano-substituent plays a special role in favoring the formation of the 6,6,5-ring fused adduct II under thermodynamically controlled conditions. The utility of the cyclo-adduct IV (BOM = CH2OCH2Ph; see Scheme 12) as a precursor for the naturally occurring histrionicotoxins is illustrated by the synthesis of three “unsym.” (i.e. with each side chain bearing different functional groups) members of the histrionicotoxin family HTX-259A, HTX-285C and HTX-285E [V; R = CH:CH2, CH2CH2CH:CH2, and CH:CHCH:CH-(Z), resp.].
Organic & Biomolecular Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, HPLC of Formula: 69361-41-7.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary