Nikiforov, Petar O. published the artcileFragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays, Name: (2-Bromoethyl)cyclopentane, the publication is ACS Chemical Biology (2017), 12(5), 1390-1396, database is CAplus and MEDLINE.
Small-mol. inhibitors of the mycobacterial transcriptional repressor EthR have previously been shown to act as boosters of the second-line antituberculosis drug ethionamide. Fragment-based drug discovery approaches have been used in the past to make highly potent EthR inhibitors with ethionamide boosting activity both in vitro and ex vivo. Herein, we report the development of fragment-sized EthR ligands with nanomolar min. effective concentration values for boosting the ethionamide activity in Mycobacterium tuberculosis whole-cell assays.
ACS Chemical Biology published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Name: (2-Bromoethyl)cyclopentane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary