Application of 74586-53-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74586-53-1, name is 3-Bromo-5-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Add m-bromoaniline (688mg, 4mmol), intermediate 3-2 (940mg, 5mmol), cuprous iodide (10%), L-proline (L-Pro, 20%) to a 25ml Shrek tube. , Cesium carbonate (2equiv) and dimethyl sulfoxide (0.5M). The resulting mixture was sparged with nitrogen for 10 minutes and stirred at 120 C for 3 days. After cooling, water and ethyl acetate (EA) were added, and the mixture was filtered. The aqueous phase was extracted with ethyl acetate, and the organic phases were combined, washed with brine, and the organic phase was dried over anhydrous Na2SO4. Using PE: EA = 10: 1 as the eluent, the obtained solution was purified by silica gel chromatography to obtain intermediate 3-3 (brown viscous liquid, yield 75%).
The synthetic route of 3-Bromo-5-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Jianuolin Optoelectric Technology Co., Ltd.; Hang Xiaochun; Yin Junli; Wang Ying; (66 pag.)CN110551157; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary