Nucleophilicity and solvent effects on the kinetics of 4-(pyren-1-yl)thiazol-2-amine interaction with 4,6-dinitrobenzofuroxan was written by El Guesmi, Nizar;Hussein, Essam M.;Asghar, Basim H.;Obaid, Rami J.;Jassas, Rabab S.;Alharbi, Ahmed;Altass, Hatem M.;Althagafi, Ismail I.;Morad, Moataz;Moussa, Ziad;Ahmed, Saleh A.. And the article was included in Arabian Journal of Chemistry in 2020.Computed Properties of C18H11BrO The following contents are mentioned in the article:
A multistep synthesis of novel pyrene-based thiazole moiety been has been realized following some synthetic challenges and complications. The chem. structure of the synthesized compound has been established on the basis of both spectroscopic and anal. tools. Its nucleophilic reactivity with 4,6-dinitrobenzofuroxan (DNBF) has been successfully studied in solution A kinetic study of the covalent electrophile/nucleophile combination of dinitrobenzofuroxan (DNBF, electrophile) and 4-(pyren-1-yl)thiazol-2-amine (nucleophile) resulting in the formation of the corresponding σ-adduct in solution is reported. The rate constant (k1) of the second-order relating to the C-C bond forming step of this complexation process has been found to fit into the linear correlation log k = sN (N + E), thereby permitting the evaluation of the nucleophilicity parameter (N) of the 4-(pyren-1-yl)thiazol-2-amine. 4-(Pyren-1-yl)thiazol-2-amine has been subsequently ranked according to its reactivity profile on the general nucleophilicity scale developed recently by Mayr et al., leading to an interesting and direct comparison over a large domain of π-, σ-, and n-nucleophiles. This study involved multiple reactions and reactants, such as 2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5Computed Properties of C18H11BrO).
2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C18H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary