Yang, Ting published the artcileDiscovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is ACS Medicinal Chemistry Letters (2014), 5(1), 65-68, database is CAplus and MEDLINE.
A novel series of tertiary amines as retinoid-related orphan receptor gamma-t (RORγt) inverse agonists was discovered through agonist/inverse agonist conversion. The level of RORγt inhibition can be enhanced by modulating the conformational disruption of H12 in RORγt LBD. Linker exploration and rational design led to the discovery of more potent indole-based RORγt inverse agonists, e.g., I.
ACS Medicinal Chemistry Letters published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C25H23NO4, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary