Adding a certain compound to certain chemical reactions, such as: 16518-62-0, name is 3-Bromo-N,N-dimethylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16518-62-0, Safety of 3-Bromo-N,N-dimethylaniline
To a solution of compoundN,N dimethyl-3-bromo aniline (10.0 g, 50.0 mmol) in AcOH (250 mL) was added 12.16 mL of 37% formaldehyde aqueous solution (4.5 g, 150.0 mmol), and the mixture was stirred at 60 C for 115 mm. After cooling to room temperature, a portion of acetic acid was removed by vacuum. Then, the reaction mixture was neutralized with saturated NaHCO3 aq. and NaOH aq., and extracted with CH2C12. The organic layer waswashed with brine, dried over Na2SO4 and evaporated to dryness. The residue was purified by flash chromatography (silica gel) to give pure 4,4?-methylenebis(3-bromo-N,N- dimethylaniline) (5.24 g, 12.7 mmol, 51% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VISEN MEDICAL, INC.; GROVES, Kevin; BUFF, Ryan; WO2014/144793; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary