Li, Yuan-Xiang published the artcileDesign and syntheses of novel phthalazin-1(2H)-one derivatives as acetohydroxyacid synthase inhibitors, Formula: C7H5Br2F, the publication is Journal of Agricultural and Food Chemistry (2006), 54(24), 9135-9139, database is CAplus and MEDLINE.
A series of 2-substituted-8-(4,6-dimethoxypyrimidin-2-yloxy)-4-methylphthalazin-1-one derivatives were designed via ortho-substituent cyclization to discover a new herbicidal lead structure. These compounds were synthesized by a seven-step route using 3-hydroxy-acetophenone as a starting material. Determination of the Ki values against wild-type A. thaliana acetohydroxyacid synthase (AHAS) (EC 4.1.3.18) indicated that some of the compounds displayed good enzyme inhibition activity comparable to that of KIH-6127. Bioassay data on weeds showed that the synthesized compounds exhibited the typical injury symptoms of AHAS-inhibiting herbicides, and some of them showed broad-spectrum and high herbicidal activities in postemergence treatments against Echinochloa crusgalli, Digitaria sanguinalis, Setaria viridis, Brassica juncea, Amaranthus retroflexus, and Chenopodium album, at an application rate of 150 g/ha. To our knowledge, this is the first report of methylphthalazin-1-one derivatives as AHAS inhibitors.
Journal of Agricultural and Food Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary