Rakowitz, Dietmar’s team published research in Archiv der Pharmazie (Weinheim, Germany) in 338 | CAS: 76283-09-5

Archiv der Pharmazie (Weinheim, Germany) published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Rakowitz, Dietmar published the artcileOn the synthesis of bioisosteres of O-benzothiazolyl-oxybenzoic acids and evaluation as aldose reductase inhibitors, Formula: C7H5Br2F, the publication is Archiv der Pharmazie (Weinheim, Germany) (2005), 338(9), 419-426, database is CAplus and MEDLINE.

A series of compounds characterized by bioisosteric replacement of pharmacophores were prepd, e.g., I (R = CH(=NOH) or NO2) and tested as aldose reductase inhibitors (ARIs). On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biol. evaluation of these derivatives permitted to gain insight into structural features critical for the aldose reductase inhibition.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary