Chen, Liu Zeng et al. published their research in European Journal of Medicinal Chemistry in 2020 | CAS: 4457-67-4

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C5H11BrO

Novel phthalide derivatives: synthesis and anti-inflammatory activity in vitro and in vivo was written by Chen, Liu Zeng;Wu, Jing;Li, Kang;Wu, Qian Qian;Chen, Rui;Liu, Xin Hua;Ruan, Ban Feng. And the article was included in European Journal of Medicinal Chemistry in 2020.COA of Formula: C5H11BrO This article mentions the following:

A three series (total of 31) novel phthalide derivatives I (R1 = Me, Ph, PhCH2, 4-PhC6H4, 4-PhOC6H4), II (R2 = H, Et, MeOCH2CH2, 4-BrC6H4CH2, etc.) and III (R3 = Me, PhCH2, 4-FC6H4CH2) were designed and synthesized, and their anti-inflammatory activities were screened in-vitro and in-vivo. The anti-inflammatory activity of all the compounds I, II and III were screened on LPS induced NO production to evaluating their inhibitory effects. Structure-activity relationship was studied, and finally compound II [R2 = 4-FC6H4CH2; (IV)] was found to be the active one with low toxicity, which showed 95.23% inhibitory rate at 10μM with IC50 value of 0.76μM against LPS-induced NO over expression. Preliminary mechanism studies indicated that compound IV activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. The in-vivo anti-inflammatory activity shown that compound IV had obvious therapeutic effect against the adjuvant-induced rat arthritis model. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4COA of Formula: C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary