A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor was written by Wheeler, Rob C.;Baxter, Emma;Campbell, Ian B.;MacDonald, Simon J. F.. And the article was included in Organic Process Research & Development in 2011.Formula: C8H6BrFO2 This article mentions the following:
Flow chem. is a rapidly emerging technol. within the pharmaceutical industry, both within medicinal and development chem. groups. The advantages of flow chem., increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technol. in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilizes flow chem. to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogs. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Formula: C8H6BrFO2).
Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C8H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary