Micellar Suzuki Cross-Coupling between Thiophene and Aniline in Water and under Air was written by Yousif, Dawod;Tombolato, Silvia;Ould Maina, Elmehdi;Po, Riccardo;Biagini, Paolo;Papagni, Antonio;Vaghi, Luca. And the article was included in Organics in 2021.Formula: C6H5Br2N This article mentions the following:
The Suzuki-Miyaura cross-coupling reaction plays a fundamental role in modern synthetic organic chem., both in academia and industry. For this reason, scientists continue to search for new, more effective, cheaper and environmentally friendly procedures. Recently, micellar synthetic chem. has been demonstrated to be an excellent strategy for achieving chem. transformations in a more efficient way, thanks to the creation of nanoreactors in aqueous environments using selected surfactants. In particular, the cheap and com. available surfactant Kolliphor EL (a polyethoxylated castor oil derivative) has been used with success to achieve metal-catalyzed transformations in water with high yields and short reaction times, with the advantage of using air-sensitive catalysts without the need for inert atm. In this work, the Kolliphor EL methodol. was applied to the Suzuki cross-coupling reaction between thiophene and aniline, using the highly effective catalyst Pd(dtbpf)Cl2. The cross-coupling products were achieved at up to 98% yield, with reaction times of up to only 15 min, working at room temperature and without the need for inert atm. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Formula: C6H5Br2N).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C6H5Br2N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary