Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent was written by Shi, Guangfa;Shao, Changdong;Pan, Shulei;Yu, Jingxun;Zhang, Yanghui. And the article was included in Organic Letters in 2015.Synthetic Route of C9H6BrF3O2 This article mentions the following:
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3ยท from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8Synthetic Route of C9H6BrF3O2).
Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C9H6BrF3O2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary