Synthesis of medium ring heterocycles using an intramolecular Heck reaction was written by Arnold, Leggy A.;Luo, Wenchen;Guy, R. Kiplin. And the article was included in Organic Letters in 2004.Name: Ethyl (2-bromophenyl)acetate This article mentions the following:
Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenz[b,f]azepine, -oxocine, and -thiocine and dibenz[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramol. Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from com. available starting materials. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Name: Ethyl (2-bromophenyl)acetate).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: Ethyl (2-bromophenyl)acetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary