Bray, H. G. et al. published their research in Biochemical Journal in 1958 | CAS: 74440-80-5

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 74440-80-5

Metabolism of ο-, m-, and p-fluoro, bromo-, and iodonitrobenzenes in the rabbit was written by Bray, H. G.;James, Sybil P.;Thorpe, W. V.. And the article was included in Biochemical Journal in 1958.Application of 74440-80-5 This article mentions the following:

The metabolism of ο-, m-, and p-fluoro-, ο-, m-, and p-bromo-, and ο-, m-, and p-iodonitrobenzenes has been studied in the rabbit. The ortho and para compounds form mercapturic acids (over 30% of the dose with the fluoro and ο-bromo compounds), but the meta compounds do not. Except with p-fluoronitrobenzene (less than 10%) about 30-60% of the dose is excreted as phenols conjugated with glucuronic and sulfuric acids; except with p-bromo- and p-iodonitrobenzenes (30%) less than 10% of the dose is excreted as the corresponding anilines. The main phenolic metabolite of p-fluoronitrobenzene is p-aminophenol. ο- and m-Fluoronitrobenzenes also probably undergo hydroxyldefluorination. Apart from hydroxyldehalogenation in the fluoro compounds the metabolic fate of the fluoro-, bromo-, and iodonitrobenzenes is, in general, qualitatively similar to that of the corresponding chloro compounds (Bray, et al., C.A. 50, 17144g). Other metabolites isolated in smaller quantities were as follows: N-acetyl-S-(2-nitrophenyl)-L-cysteine, N-acetyl-S-(4-nitrophenyl)-L-cysteine, p- and m-fluoroanilines, 4-amino-2-fluorophenol, ο- and m-bromoanilines, 4-amino-3- and 4-amino-2-bromophenols, 2-amino-4-, 2-amino-5-, 2-amino-6-bromophenols, ο-, m-, and p-iodoanilines, 4-amino-3- and 2-amino-5-iodophenols. The Rf values of the various metabolites in several solvent mixtures have been determined and recorded. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Application of 74440-80-5).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 74440-80-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary