3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 3-Bromo-4-fluorocinnamic acid
Synthesis and anti-influenza activities of novel baicalein analogs was written by Chung, Shu-Ting;Chien, Pei-Yu;Huang, Wen-Hsin;Yao, Chen-Wen;Lee, An-Rong. And the article was included in Chemical & Pharmaceutical Bulletin in 2014.Application In Synthesis of 3-Bromo-4-fluorocinnamic acid This article mentions the following:
A series of novel flavones derivatives were synthesized based on modification of the active ingredients of a traditional Chinese medicine Scutellaria baicalensis GEORGI screened for anti-influenza activity. The synthetic baicalein (flavone) analogs, especially with the B-rings substituted with bromine atoms, were much more potent than oseltamivir or ribavirin against H1N1 Tamiflu-resistant (H1N1 TR) virus and usually with more favorable selectivity. The most promising were I (R = OM, R1 = 3-BrPh or 4-BrPh; R = OH, R1 = 3-BrPh or 4-BrPh) all displaying an 50% effective concentration (EC50) at around 4.0-4.5 μM, and a selective index (SI = 50% cytotoxic concentration (CC50)/EC50)>70. For seasonal H3N2-infected influenza virus, both I (R = OM, R1 = 2-BrPh or 3-BrPh) with SI >17.3 indicated superior to ribavirin. The flavonoids having both not-naturally-occurring bromo-substituted B-rings and appropriate hydroxyls positioning on the A-rings might be critical in determining the activity and selectivity against H1N1-Tamiflu-resistant infected influenza viruses. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1Application In Synthesis of 3-Bromo-4-fluorocinnamic acid).
3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 3-Bromo-4-fluorocinnamic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary