Selenium-Catalyzed Carbonylative Synthesis of 3,4-Dihydroquinazolin-2(1H)-one Derivatives with TFBen as the CO Source was written by Zhou, Rong;Qi, Xinxin;Wu, Xiao-Feng. And the article was included in ACS Combinatorial Science in 2019.Recommanded Product: 76437-44-0 This article mentions the following:
An efficient and general carbonylative procedure for the synthesis of 3,4-dihydroquinazolin-2(1H)-one from 1-(halomethyl)-2-nitrobenzenes and aryl/alkyl amines have been explored. In this approach, to avoid of using toxic CO gas, a solid and stable CO precursor, TFBen (benzene-1,3,5-triyl triformate), was utilized. With elemental selenium as the catalyst, a variety of aryl/alkyl amines has been tolerated well to afford the corresponding 3,4-dihydroquinazolin-2(1H)-one products in moderate to excellent yields under mild reaction condition. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Recommanded Product: 76437-44-0).
1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 76437-44-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary