Synthesis and chemoselective ligations of MIDA acylboronates with O-Me hydroxylamines was written by Noda, Hidetoshi;Bode, Jeffrey W.. And the article was included in Chemical Science in 2014.COA of Formula: C9H11BrO This article mentions the following:
N-Methyliminodiacetyl (MIDA) acylboronates undergo chemoselective amide-bond forming ligations in water with O-Me hydroxylamines, including unprotected peptide substrates. These bench-stable boronates were easily prepared from potassium acyltrifluoroborates (KATs) in one step. The reactivity of MIDA acylboronates with O-alkylhydroxylamines – which are unreactive with KATs – was attributed to the nature of the neutral MIDA boronates vs. the ionic KATs, leading to differences in the stability of likely intermediates and propensity for elimination. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0COA of Formula: C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary