RhII-Catalyzed Intermolecular C-H Arylation of Aromatics with Diazo Quinones was written by Wu, Kai;Cao, Bei;Zhou, Cong-Ying;Che, Chi-Ming. And the article was included in Chemistry – A European Journal in 2018.Computed Properties of C6H6BrNO This article mentions the following:
An efficient synthesis of biaryls R-R1 [R = 4-H3COC6H4, thiophen-2-yl, 2-methoxynaphthalen-1-yl, 1,3-benzothiazol-2-yl, etc.; R1 = 2-OH-3,5-Cl2C6H2, 2-Br-4-HOC6H3, 3-C(O)OCH3-4-HOC6H3, etc.] by a dirhodium(II)-catalyzed aromatic C-H arylation with diazo quinones such as 4-bromo-6-diazocyclohexa-2,4-dien-1-one, 2,6-dichloro-4-diazocyclohexa-2,5-dien-1-one, 3-bromo-4-diazocyclohexa-2,5-dien-1-one, etc. has been developed. The new biaryl synthesis can be performed under mild and neutral conditions and without directing group chelation assistance. The reaction tolerates various functionalities and is applicable to a broad range of aromatics The regioselectivity of the C-H arylation was often high and predictable. The synthetic utility of the method was demonstrated by the late-stage modifications of a series of pharmaceuticals and functional materials as well as a short synthesis of a transthyretin amyloid inhibitor e.g., Me 2-hydroxy-5-(2-methoxy-6-(3-oxobutyl)naphthalen-1-yl)benzoate. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Computed Properties of C6H6BrNO).
4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C6H6BrNO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary