Studies on prostaglandins. VI. Synthesis of 16(S)-methyl-20-methoxy-PGE2 (YPG-209) having oral bronchodilator activity and its analogs was written by Iwamoto, Hidenori;Inukai, Noriyoshi;Yanagisawa, Isao;Ishii, Yoshio;Tamura, Toshinari;Shiozaki, Tetsuya;Takagi, Tokuichi;Tomioka, Kenichi;Murakami, Masuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1980.HPLC of Formula: 4457-67-4 This article mentions the following:
16(S)-Methyl-2-methoxy-PGE2 (I), 16(R)-methyl-2-methoxy-PGE2 (II) and several analogs, such as 16(S)-methyl-20-methoxy-PGA2 and -PGB2, 16-methyl-20-ethoxy-PGE2, 16-methyl-20-(hydroxymethyl)-PGE2, 16-methyl-17-oxa-ω-dihomo-PGE2, and 20-(hydroxymethyl)-PGE2, were prepared I and II had potent oral bronchodilator activity; the bronchoselectivity of I was higher than that of II. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4HPLC of Formula: 4457-67-4).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 4457-67-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary