Chemoselective Preparation of “Clickable” Aryl Sulfonyl Fluoride Monomers:A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis was written by Fadeyi, Olugbeminiyi;Parikh, Mihir;Chen, Ming;Kyne, Robert Jr.;Taylor, Alexandria;O’Doherty, Inish;Kaiser, Stephen;Barbas, Sabrina;Niessen, Sherry;Shi, Manli;Weinrich, Scott L.;Kath, John;Jones, Lyn;Robinson, Ralph Pelton. And the article was included in ChemBioChem in 2016.COA of Formula: C6H4BrFO2S This article mentions the following:
Sulfonyl fluoride (SF)-based activity probes have become important tools in chem. biol. Herein, exploiting the relative chem. stability of SF to carry out a number of unprecedented SF-sparing functional group manipulations, we report the chemoselective synthesis of a toolbox of highly functionalized aryl SF monomers that we have used to quickly prepare SF chem. biol. probes. In addition to SF, the monomers bear an embedded click handle (a terminal alkyne that can perform copper(I)-mediated azide alkyne cycloaddition). The monomers can be used either as fragments to prepare clickable SF analogs of drugs (biol. active compounds) bearing an aryl ring or, alternatively, attached to drugs as “minimalist” clickable aryl SF substituents. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9COA of Formula: C6H4BrFO2S).
3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.COA of Formula: C6H4BrFO2S
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary