Target-Selective Fluorescence Imaging and Photocytotoxicity against H2O2 High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent was written by Takagi, Ryoma;Takeda, Ayano;Takahashi, Daisuke;Toshima, Kazunobu. And the article was included in Chemistry – An Asian Journal in 2017.Synthetic Route of C7H7BrO2 This article mentions the following:
A purpose-designed and synthesized H2O2-reactive and photoactivatable theranostic agent I consisting of 1) an arylboronic acid moiety, 2) pro-fluorophore moiety, and 3) photoactivatable moiety (photosensitizer), selectively and effectively reacted with H2O2 while simultaneously releasing resorufin for fluorescence detection under neutral aqueous conditions. In addition, I was cell-permeable, and exhibited effective photocytotoxicity against fluorescently visualized cells only upon photoirradiation The results also showed that I produced a selective fluorescence response to H2O2, even in living cultured cells. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-(hydroxymethyl)phenol (cas: 170434-11-4Synthetic Route of C7H7BrO2).
5-Bromo-2-(hydroxymethyl)phenol (cas: 170434-11-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C7H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary