Heterobiaryl Human Immunodeficiency Virus Entry Inhibitors was written by Lu, Rong-Jian;Tucker, John A.;Pickens, Jason;Ma, You-An;Zinevitch, Tatiana;Kirichenko, Olga;Konoplev, Vitalii;Kuznetsova, Svetlana;Sviridov, Sergey;Brahmachary, Enugurthi;Khasanov, Alisher;Mikel, Charles;Yang, Yang;Liu, Changhui;Wang, Jian;Freel, Stephanie;Fisher, Shelly;Sullivan, Alana;Zhou, Jiying;Stanfield-Oakley, Sherry;Baker, Brian;Sailstad, Jeff;Greenberg, Michael;Bolognesi, Dani;Bray, Brian;Koszalka, Barney;Jeffs, Peter;Jeffries, Cynthia;Chucholowski, Alexander;Sexton, Connie. And the article was included in Journal of Medicinal Chemistry in 2009.Safety of Methyl 4-bromo-2-fluorobenzoate This article mentions the following:
Previously disclosed HIV (human immunodeficiency virus) attachment inhibitors, exemplified by BMS 806 (formally BMS 378806), are characterized by a substituted indole or azaindole ring linked to a benzoylpiperazine via a ketoamide or sulfonamide group. In the present report, we describe the discovery of a novel series of potent HIV entry inhibitors in which the indole or azaindole ring of previous inhibitors is replaced by a heterobiaryl group. Several of these analogs exhibited IC50 values of less than 5 nM in a pseudotyped antiviral assay, and a methylisoxazolylphenyloxoacetyl piperazine was demonstrated to exhibit potency and selectivity similar to those of BMS 378806 against a panel of clin. viral isolates. Moreover, current structure-activity relation studies of these novel biaryl gp120 inhibitors revealed that around the biaryl, a fine crevice might exist in the gp120 binding site. Taken in sum, these data reveal a hitherto unsuspected flexibility in the structure-activity relationships for these inhibitors and suggest new avenues for exploration and gp120 inhibitor design. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Safety of Methyl 4-bromo-2-fluorobenzoate).
Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Methyl 4-bromo-2-fluorobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary