An improved procedure for the oxidation of 2,5- and 5,6-dihalo-3-methylpyridines was written by Setliff, F. L.;Huie, W. R.;Adams, R. L.. And the article was included in Organic Preparations and Procedures International in 1983.Name: 5-Bromo-2-fluoronicotinic acid This article mentions the following:
Nicotinic acids I (R = Br, Cl, F; R1 = iodo, Br, Cl) were obtained from methylpyridines II and Bu4N+ MnO4–. Similarly prepared were acids III (R2 = Br, Cl). 5,6-Dibromo-3-methylpyridine in pyridine was oxidized by Bu4N+ MnO4– at 75-80° to give III (R2 = Br). In the experiment, the researchers used many compounds, for example, 5-Bromo-2-fluoronicotinic acid (cas: 29241-66-5Name: 5-Bromo-2-fluoronicotinic acid).
5-Bromo-2-fluoronicotinic acid (cas: 29241-66-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 5-Bromo-2-fluoronicotinic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary